THE IMPACT OF KETOGENIC DIET ON HORMONE LEVELS IN WOMEN WITH POLYCYSTIC OVARY SYNDROME: A SYSTEMATIC REVIEW

Background: There is a complex and multifaceted association between hormone levels in women with Polycystic Ovary Syndrome (PCOS) and the ketogenic diet.  Objectives: To conduct a thorough evaluation and analysis of the literature on the impact of the ketogenic diet on PCOS-affected women's hormone levels. Methods: A comprehensive exploration of relevant databases was conducted to identify studies meeting the inclusion criteria. To locate relevant literature, a comprehensive search of PubMed, Web of Science, SCOPUS, and Science Direct was carried out. The entire procedure made use of the Rayyan QRCI. Results: Six trials including 506 women in total were included in our data. The follow-up duration ranged from 45 days and 12 weeks. All of the included studies recorded significant reductions in the mean levels of total testosterone and LH/FSH ratio following the ketogenic diet women among women with PCOS. The ketogenic diet also positively affected menstrual regularity, metabolic parameters, anthropometric parameters, and endocrine parameters. Thus, ketogenic diet is a potential treatment option for PCOS. Conclusion: The extent to which these findings may be extensively applied to the PCOS community is limited by the numerous concerns that remain in the accessible literature and require closer examination. However, these findings have important treatment implications, and endocrinologists, gynecologists, and dieticians should carefully plan and modify particular meal recommendations for women with PCOS. Finding the potential for nutritional therapies that can support individualized preventive tactics to safeguard fertility beginning in youth is critical given the long-term effects of PCOS.

Keywords: Ketogenic diet, hormone levels, Polycystic Ovary Syndrome, endocrine disorders, testosterone, hormonal balance, metabolic health, hormone regulation.