Positive effects of bariatric surgery are associated with attenua tion of cellular senescence

Background and aims: Bariatric surgery represents the most effi
cient approach to treatment of obesity. However, the detailed mecha
nism of its positive metabolic effect is still not fully understood. Cel
lular senescence arrests damaged cells thus prevents further spreading 
of the damage. Persistence of senescent cells especially in adipose 
tissue can, however, contribute to the development of a number of 
chronic diseases including obesity and its complications. Reduction 
of adipose tissue after bariatric surgery can therefore reduce the num
ber of senescent cells and their negative effects on organism.