Published June 17, 2016
| Version 2
Dataset
Open
Human Histone Deacetylase 6 (HDAC6); A Target Enabling Package
Description
HDAC6 is a cytosolic deacetylase with diverse roles in cellular trafficking, autophagy and cell signalling. Specifically targeting the unique zinc-finger ubiquitin-binding domain (ZnF-UBD) of HDAC6 may be an attractive strategy in myeloma and lymphoma but no inhibitor has been reported to date. Presented here are 4 co-crystal structures of HDAC6 ZnF-UBD in complex with different compounds, and associated SPR, ITC and FP assays.
Notes
This deposition represents version 2 of the TEP datasheet. Changes include, but are not limited to: Addition of hyperlinks throughout the body of the datasheet; Addition of Useful Links to relevant databases; Addition of a Reference box where applicable; Other modifications necessary for page spacing and visualisation. Please note, all data and results within the document remain the same as provided in version 1.
Files
HDAC6_TEP_datasheet_v2.pdf
Files
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Additional details
Related works
- Is part of
- https://www.thesgc.org/tep (URL)