DNA CLEAVAGE POTENTIAL OF 4-(PIPERIDIN-1- YLMETHYL)-2-(THIOPHEN-2-YL) QUINOLINE ANALOGUES

DNA cleavage potential of 4-(piperidin-1-ylmethyl)-2-(thiophen-2-yl) quinoline 7(a-j) derivatives, were studied on Calf-thymus DNA by agarose gel electrophoresis method. The compounds 7e and 7j have exhibited almost complete cleavage, whereas the other compounds 7a, 7b, 7c, 7d, 7f, 7g and 7i have shown partial cleavage of DNA at 100 μg concentration. The compounds 7e and 7j can be considered as DNA intercalating agents due to its planarity and their potentiality to cleave the DNA completely. This might be through breaking the base pairs of DNA. Keywords: DNA, Calf-thymus DNA, Thiophene, Agarose gel electrophoresis.