Published June 17, 2016
| Version 1
Dataset
Open
Human Histone Deacetylase 6 (HDAC6); A Target Enabling Package
Description
HDAC6 is a cytosolic deacetylase with diverse roles in cellular trafficking, autophagy and cell signalling. Specifically targeting the unique zinc-finger ubiquitin-binding domain (ZnF-UBD) of HDAC6 may be an attractive strategy in myeloma and lymphoma but no inhibitor has been reported to date. Presented here are 4 co-crystal structures of HDAC6 ZnF-UBD in complex with different compounds, and associated SPR, ITC and FP assays.
Files
HDAC6_TEP_datasheet_v1.pdf
Files
(948.8 kB)
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Additional details
Related works
- Is part of
- https://www.thesgc.org/tep (URL)