Published June 17, 2016
| Version 1
Dataset
Open
Lysine Demethylase JMJD1B (KDM3B); A Target Enabling Package
Description
There are 3 members of the Lysine Demethylase JMJD1 (KDM3) family, JMJD1A-C. SGC Oxford has expressed, purified and crystallized the catalytic domains of JMJD1A, JMJD1B and JMJD1C as part of the probe programme. Fragment screening and X-ray crystallography identified a large number of binders, some of which were progressed into a medicinal chemistry programme. Despite significant effort molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.
Notes
The work at the SGC has been supported by the Innovative Medicines Initiative Joint Undertaking (IMI JU) under grant agreement [115766].
Files
JMJD1B_TEP_datasheet_v1.pdf
Files
(1.4 MB)
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Additional details
Related works
- Is part of
- https://www.thesgc.org/tep (URL)