Published March 30, 2017 | Version v1
Journal article Open

Antiviral Resistance of Splenocytes in Aged Mice

Authors/Creators

  • 1. InstituteofImmunologyandExperimentalTherapyPolishAcademyofSciencesDepartmentofExperimentalTherapyWrocawPoland
  • 2. DepartmentofNeurosurgeryUlmUniversityMedicalCentreUlmGermany
  • 3. UniversityofTexasHoustonMedicalSchoolHoustonTXUSA

Description

We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with Encephalomyocarditis virus (EMCV). Recombinant mouse lactoferrin (rmLF) and bovine lactoferrin (bLF) were used. There were no differences in the susceptibility to EMCV infection in the studied age categories. Both types of lactoferrins were protective in young and old mice. The study confirmed the undisturbed viral resistance in old mice and the protective actions of lactoferrin in viral infection. The antiviral action of the homologous mouse lactoferrin was demonstrated for the first time.

Files

10.5604_17331331.1235002.pdf

Files (321.9 kB)

Name Size Download all
md5:7d1adf2b8b9022cfedf8478532751337
321.9 kB Preview Download