Spectrum of Infections and Antibiotic Susceptibility Pattern of Pseudomonas aeruginosa in a Tertiary Care Hospital
Authors/Creators
- 1. Associate Professor, Department of Microbiology, Tripura Medical College &Dr. BR Ambedkar Memorial Teaching Hospital, Agartala, Tripura, India
- 2. Assistant Professor, Department of Microbiology, Tripura Medical College &Dr. BR Ambedkar Memorial Teaching Hospital, Agartala, Tripura, India
- 3. Assistant Professor, Department of Pathology, Tripura Medical College &Dr. BR Ambedkar Memorial Teaching Hospital, Agartala, Tripura, India
- 4. Professor & Head, Department of Pathology, Tripura Medical College &Dr. BR Ambedkar Memorial Teaching Hospital, Agartala, Tripura, India
- 5. Senior Resident, Department of Pathology, Tripura Medical College &Dr. BR Ambedkar Memorial Teaching Hospital, Agartala, Tripura, India
Description
Background : Pseudomonas aeruginosa can cause serious nosocomial and community acquired infections with limited therapeutic options due to their intrinsic resistance to several antibiotics and rapid development of multiple drug resistance mechanisms. This study aims to determine the infections caused by Pseudomonas aeruginosa and analyze the antibiotic susceptibility pattern to establish the current therapeutic options. Materials and Methods: The study was conducted on 166 strains of Pseudomonas aeruginosa isolated from various clinical samples. Isolation and confirmation of the organism in culture was performed using standard microbiological techniques. The antibiotic susceptibility testing was performed by Kirby Bauer disc diffusion method. Results: The predominant infections caused by Pseudomonas aeruginosa included Pneumonia (52.4%) followed by Urinary tract infection (28.9%). All isolates were sensitive to Colistin. Other effective antibiotics against Pseudomonas aeruginosa were Imipenem (80.7%), Meropenem (78.9%), Piperacillin tazobactum (77.7%) and Netilmicin (72.9%). The isolates were mostly resistant to fluoroquinolones and Antipseudomonal Cephalosporins. Multidrug resistance were observed in 34.3% isolates. Conclusion: Lower respiratory tract infection and urinary tract infection were the common infections caused by Pseudomonas aeruginosa. Piperacillin tazobactum and/or Netilmicin may be considered for empirical treatment of suspected infection. Use of carbapenems and colistin may be restricted to multidrug resistant strains causing serious infections and those resistant to all other classes of antibiotics. Definitive treatment should be based on the culture and sensitivity test results only.
Abstract (English)
Background : Pseudomonas aeruginosa can cause serious nosocomial and community acquired infections with limited therapeutic options due to their intrinsic resistance to several antibiotics and rapid development of multiple drug resistance mechanisms. This study aims to determine the infections caused by Pseudomonas aeruginosa and analyze the antibiotic susceptibility pattern to establish the current therapeutic options. Materials and Methods: The study was conducted on 166 strains of Pseudomonas aeruginosa isolated from various clinical samples. Isolation and confirmation of the organism in culture was performed using standard microbiological techniques. The antibiotic susceptibility testing was performed by Kirby Bauer disc diffusion method. Results: The predominant infections caused by Pseudomonas aeruginosa included Pneumonia (52.4%) followed by Urinary tract infection (28.9%). All isolates were sensitive to Colistin. Other effective antibiotics against Pseudomonas aeruginosa were Imipenem (80.7%), Meropenem (78.9%), Piperacillin tazobactum (77.7%) and Netilmicin (72.9%). The isolates were mostly resistant to fluoroquinolones and Antipseudomonal Cephalosporins. Multidrug resistance were observed in 34.3% isolates. Conclusion: Lower respiratory tract infection and urinary tract infection were the common infections caused by Pseudomonas aeruginosa. Piperacillin tazobactum and/or Netilmicin may be considered for empirical treatment of suspected infection. Use of carbapenems and colistin may be restricted to multidrug resistant strains causing serious infections and those resistant to all other classes of antibiotics. Definitive treatment should be based on the culture and sensitivity test results only.
Files
IJPCR,Vol15,Issue7,Article145.pdf
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Additional details
Dates
- Accepted
-
2023-06-25
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue7,Article145.pdf
- Development Status
- Active
References
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