Comparative Evaluation of Propofol-Ketamine and Propofol-Fentanyl Combination For minor Surgical Procedures
Authors/Creators
- 1. Associate Professor, Department of Anaesthesiology, Thanjavur Medical College and Hospital, Thanjavur
- 2. Assistant Professor, Department of Anaesthesiology, Dhanalakshmi Srinivasan Medical College and Hospital, Perambalur
- 3. Assistant Professor, Department of Anaesthesiology, Thanjavur Medical College and Hospital, Thanjavur
Description
Combining a sedative agent with an analgesic agent for short surgical procedures done under intravenous sedation can offer a lot of advantages especially when short acting agents are chosen. In our study we combined propofol with either ketamine or fentanyl and formed two groups of patients undergoing short surgical procedures with 40 members in each group. Group I received Inj ketamine 0.5 mg/kg over 2 minutes followed by Inj propofol at rate of 1 ml over 3 seconds till the end point of induction. Group II received injection fentanyl 1.5 µg/kg followed by 1 ml propofol till the end point of induction. Parameters assessed include hemodynamics, recovery profile and complications. Data were collected and analysed using appropriate statistical tests. Results: Demographic profile was comparable between the two groups. Pulse rate, systolic blood pressure, respiratory rate were statistically better in Group I(Ketamine) and diastolic blood pressure and saturation were comparable. But clinically the changes were insignificant. Recovery profile was better with Group II. Complications like pain at the site of injection, PONV were more in Group II. Conclusion: Both combinations are clinically effective and comparable with some advantages favouring Ketamine group (Group I).
Abstract (English)
Combining a sedative agent with an analgesic agent for short surgical procedures done under intravenous sedation can offer a lot of advantages especially when short acting agents are chosen. In our study we combined propofol with either ketamine or fentanyl and formed two groups of patients undergoing short surgical procedures with 40 members in each group. Group I received Inj ketamine 0.5 mg/kg over 2 minutes followed by Inj propofol at rate of 1 ml over 3 seconds till the end point of induction. Group II received injection fentanyl 1.5 µg/kg followed by 1 ml propofol till the end point of induction. Parameters assessed include hemodynamics, recovery profile and complications. Data were collected and analysed using appropriate statistical tests. Results: Demographic profile was comparable between the two groups. Pulse rate, systolic blood pressure, respiratory rate were statistically better in Group I(Ketamine) and diastolic blood pressure and saturation were comparable. But clinically the changes were insignificant. Recovery profile was better with Group II. Complications like pain at the site of injection, PONV were more in Group II. Conclusion: Both combinations are clinically effective and comparable with some advantages favouring Ketamine group (Group I).
Files
IJPCR,Vol15,Issue7,Article62.pdf
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Additional details
Dates
- Accepted
-
2023-05-25
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue7,Article62.pdf
- Development Status
- Active
References
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