Assessment of the Association between Bone Metabolic Markers and CAD Risk Score: An Observational Study
Authors/Creators
- 1. 1Assistant Professor, Department of Cardiology, Narayan Medical College and Hospital, Sasaram, Rohtas, Bihar, India
- 2. Consulatant, Radiologist, Bihar Diagnostics and Imaging, Patna, Bihar, India
Description
Abstract
Aim: The aim of the present study to analyze the association between bone metabolic markers and CAD risk
score in the general population of Bihar region.
Material & Methods: The present study was conducted at Department of Cardiology, Total 2000 participants
were included in the study.
Results: There were 60% females and 40% males. Participants had co-morbidities like diabetes mellitus,
dyslipidaemia, hypertension. The median Suita score was 43 points, and the median baPWV was 1,432 cm/s.
TP1NP level was negatively associated with the CAD high-risk subgroup (Suita score ≥ 56) (odds ratio (OR) =
0.78, 95% confidence interval (CI) = 0.69–0.82, P < 0.001). There were significant differences in age, sex,
history of smoking, history of diabetes, history of CAD, body mass index (BMI), SBP, DBP, baPWV, Suita
score, total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, creatinine, uric acid, corrected calcium,
phosphorus, hemoglobin, hemoglobin A1c, and N-terminal fragment of pro-B-type natriuretic peptide (NTproBNP). Significant differences were observed in age, sex, smoking history, dyslipidemia history, hypertension
history, BMI, SBP, DBP, baPWV, Suita score, total cholesterol, tri- glyceride, HDL cholesterol, LDL
cholesterol, creatinine, eGFR, uric acid, corrected calcium, phosphorus, hemoglobin, and hemoglobin A1c.
Significant differences were observed in age, sex, smoking history, diabetes history, hypertension history, CAD
history, BMI, SBP, DBP, Suita score, total cholesterol, triglyceride, HDL cholesterol, LDL cholesterol,
creatinine, uric acid, corrected calcium, phosphorus, hemoglobin, and hemoglobin A1c.
Conclusion: This study demonstrated that TP1NP levels decreased in participants with high Suita scores and
high baPWV, suggesting that TP1NP down regulation may indicate future CAD risk and atherosclerosis
progression in the general population of Bihar
Abstract (English)
Abstract
Aim: The aim of the present study to analyze the association between bone metabolic markers and CAD risk
score in the general population of Bihar region.
Material & Methods: The present study was conducted at Department of Cardiology, Total 2000 participants
were included in the study.
Results: There were 60% females and 40% males. Participants had co-morbidities like diabetes mellitus,
dyslipidaemia, hypertension. The median Suita score was 43 points, and the median baPWV was 1,432 cm/s.
TP1NP level was negatively associated with the CAD high-risk subgroup (Suita score ≥ 56) (odds ratio (OR) =
0.78, 95% confidence interval (CI) = 0.69–0.82, P < 0.001). There were significant differences in age, sex,
history of smoking, history of diabetes, history of CAD, body mass index (BMI), SBP, DBP, baPWV, Suita
score, total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, creatinine, uric acid, corrected calcium,
phosphorus, hemoglobin, hemoglobin A1c, and N-terminal fragment of pro-B-type natriuretic peptide (NTproBNP). Significant differences were observed in age, sex, smoking history, dyslipidemia history, hypertension
history, BMI, SBP, DBP, baPWV, Suita score, total cholesterol, tri- glyceride, HDL cholesterol, LDL
cholesterol, creatinine, eGFR, uric acid, corrected calcium, phosphorus, hemoglobin, and hemoglobin A1c.
Significant differences were observed in age, sex, smoking history, diabetes history, hypertension history, CAD
history, BMI, SBP, DBP, Suita score, total cholesterol, triglyceride, HDL cholesterol, LDL cholesterol,
creatinine, uric acid, corrected calcium, phosphorus, hemoglobin, and hemoglobin A1c.
Conclusion: This study demonstrated that TP1NP levels decreased in participants with high Suita scores and
high baPWV, suggesting that TP1NP down regulation may indicate future CAD risk and atherosclerosis
progression in the general population of Bihar
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Additional details
Dates
- Accepted
-
2023-09-27