A Study of Serum Bilirubin in Coronaryartery Disease Patient in Age Group of 35-70 in a Tertiary Medical Centre
Authors/Creators
- 1. Post graduate, Department of General Medicine, Shree Balaji Medical College and Hospital, Chennai, India
- 2. Associate Professor, Department of General Medicine, Shree Balaji Medical College and Hospital, Chennai, India
Description
Abstract: Coronary artery disease (CAD) is a major cause of morbidity, mortality, and healthcare expenditure.
A number of environmental and genetic risk factors have been known to contribute to CAD. More recently, a
number of studies have supported as well as opposed a possible protective benefit of bilirubin in CAD, since it
has anti-inflammatory, antioxidant, and antiaggregatory properties that may reduce atherogenesis. It also shares
associations with different forms of CAD, namely stable CAD, unstable angina pectoris, stable angina pectoris,
and acute myocardial infarction. Lack of sufficient evidence, however, has failed to elucidate a causal
relationship between serum bilirubin level and risk of CAD. Therefore, in this update, we attempted to simplify
this intricate relationship between bilirubin and CAD, revisit the pathophysiology of disease, how bilirubin may
be protective, and to summarize the findings of the current literature
Abstract (English)
Abstract: Coronary artery disease (CAD) is a major cause of morbidity, mortality, and healthcare expenditure.
A number of environmental and genetic risk factors have been known to contribute to CAD. More recently, a
number of studies have supported as well as opposed a possible protective benefit of bilirubin in CAD, since it
has anti-inflammatory, antioxidant, and antiaggregatory properties that may reduce atherogenesis. It also shares
associations with different forms of CAD, namely stable CAD, unstable angina pectoris, stable angina pectoris,
and acute myocardial infarction. Lack of sufficient evidence, however, has failed to elucidate a causal
relationship between serum bilirubin level and risk of CAD. Therefore, in this update, we attempted to simplify
this intricate relationship between bilirubin and CAD, revisit the pathophysiology of disease, how bilirubin may
be protective, and to summarize the findings of the current literature
Files
IJCPR,Vol15,Issue10,Article63.pdf
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Additional details
Dates
- Accepted
-
2023-08-15