Analysis of the Addition of Clonidine and Fentanyl Addition to the Bupivacaine for Caesarean Section
Authors/Creators
- 1. Assistant Professor, Department of Anesthesia, Gujarat Adani Institute of Medical Science, Bhuj, Kutch, Gujarat
- 2. Associate Professor, Department of Anesthesia, Gujarat Adani Institute of Medical Science, Bhuj, Kutch, Gujarat
Description
Background: Intrathecal opiods enhance analgesia from subtherapeutic dose of local anesthetic and make it possible to achieve successful spinal anaesthesia using otherwise inadequate doses of local anesthetic. Hence the aim of the present study was to evaluate the effects of fentanyl and clonidine added to Bupivacaine, for caesarean section in spinal Anaesthesia. Materials & Methods: Patients were randomly allocated into 3 groups of 80 each. A- Control Group – Injection (0.5%) Bupivacaine 1.8 ml + 0.4 ml NS, B- Study group 1 inj. (0.5%) Bupivacaine 1.8 ml + Clonidine 30 μg) + 0.2 ml NS, C- Study group 2 Inj (0.5%) Bupivacaine 1.8 ml + Clonidine (30 μg) +fentanyl (10μg). Total duration of analgesia was taken as the period from the time of giving subarachnoid block till the patient’s first requirement of analgesic medication. Results: The pain free time between the groups were compared in the table 1. The means of three groups were 131.5 ± 25.5, 182.6 ± 18.3 and 224.2 ± 29.2 respectively. They were significantly differed between them. The sedation levels of three groups were associated in the above table 2. The sedation level 1 was associated with groups A and B. The sedation level 2 was associated with group C. The above associations were statistically very highly significant. Conclusion: The above study bears out the following facts. Intrathecal clonidine and the clonidine fentanyl combination, both improved quality of Intra Operative analgesia. Combination of clonidine with fentanyl increased the intra operative analgesic efficacy and significantly prolonged postoperative analgesia compared with clonidine alone.
Abstract (English)
Background: Intrathecal opiods enhance analgesia from subtherapeutic dose of local anesthetic and make it possible to achieve successful spinal anaesthesia using otherwise inadequate doses of local anesthetic. Hence the aim of the present study was to evaluate the effects of fentanyl and clonidine added to Bupivacaine, for caesarean section in spinal Anaesthesia. Materials & Methods: Patients were randomly allocated into 3 groups of 80 each. A- Control Group – Injection (0.5%) Bupivacaine 1.8 ml + 0.4 ml NS, B- Study group 1 inj. (0.5%) Bupivacaine 1.8 ml + Clonidine 30 μg) + 0.2 ml NS, C- Study group 2 Inj (0.5%) Bupivacaine 1.8 ml + Clonidine (30 μg) +fentanyl (10μg). Total duration of analgesia was taken as the period from the time of giving subarachnoid block till the patient’s first requirement of analgesic medication. Results: The pain free time between the groups were compared in the table 1. The means of three groups were 131.5 ± 25.5, 182.6 ± 18.3 and 224.2 ± 29.2 respectively. They were significantly differed between them. The sedation levels of three groups were associated in the above table 2. The sedation level 1 was associated with groups A and B. The sedation level 2 was associated with group C. The above associations were statistically very highly significant. Conclusion: The above study bears out the following facts. Intrathecal clonidine and the clonidine fentanyl combination, both improved quality of Intra Operative analgesia. Combination of clonidine with fentanyl increased the intra operative analgesic efficacy and significantly prolonged postoperative analgesia compared with clonidine alone.
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IJTPR,Vol12,Issue7,Article1.pdf
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Additional details
Dates
- Accepted
-
2022-06-01
Software
References
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