DESIGN AND DEVELOPMENT OF ORAL MEDICATED GEL OF FERROUS FUMARATE

The present study aimed to develop Ferrous Fumarate oral jellies for the treatment ofirondeficiencyanemia. The sejellies were prepared by using Carbapo l940 ortragacanth with different concentrations as a gelling agent. The benefits of these prepared jellies are increased bioavailability by-passing first pass metabolism. Difficulty in swallowing (dysphagia) is common among all groups, especially in elderly and pediatrics. The persons suffering from dysphagia may getc hoked when they consume liquid formulations, thus to alleviate such problem liquid formulations of high viscosity were prepared. Various parameters like appearance, viscosity, pH, spreadibility, syneresis and drug content were performed and all were shown satisfactory results. The in-vitro dissolution test was performed in 1% SLS using USP apparatus type II (paddle), at 75 rpm. The formulations with Tragacanth10%(F8) and Carbapol940(10%)(F10)were selected for further stability studies because these formulations shows better results in all the parameters.

Keywords: Ferrousfumarate, Carbapol940, medicated  gel.