The Bidirectional Relationship between Diabetes Mellitus and Major Depressive Disorder: A Retrospective Cohort Study
- 1. Associate Professor, Department of Chest & Tuberculosis, Anugraha Narayan Medical College and Hospital, Gaya, Bihar
- 2. Assistant Professor, Department of Psychiatry, Mahatma Gandhi Medical College and Hospital, Tatanagar, Jharkhand
- 3. Assistant Professor, Department of Psychiatry, Sheikh Bhikari Medical College and Hospital Hazaribagh, Jharkhand
Description
Background: Diabetes Mellitus (DM) and Major Depressive Disorder (MDD) are prevalent, chronic conditions that frequently occur together. The mutual influence between these disorders has significant implications for healthcare administration. This study aims to investigate the retrospective biological and psychosocial aspects and the epidemiological association between type 2 diabetes and major depressive disorder. Methods: 500 people aged 18 to 65 participated in a retrospective cohort study. Group A consisted of 250 people with a confirmed diagnosis of DM, while Group B consisted of 250 people with a confirmed diagnosis of MDD. Participants initially completed questionnaires regarding their demographics, medical histories, and mental health. Over five years, Group A participants were monitored for the development of MDD, while Group B participants were observed for the development of diabetes. Regression models and survival analyses were utilised to quantify the strength and direction of the association. Results: The correlation between diabetes and MDDare shown to go both ways in the cohort study. During the observation period, 65 people in Group A (26% of the total) were diagnosed with MDD. Participants with DM had a significantly increased risk of acquiring MDD compared to the general population (adjusted hazard ratio = 1.82, p< 0.001). During the observation period, Type 2 diabetes occurred in 53 people in Group B, or 21 per cent. Individuals with MDD were more likely to develop DM than those without MDD (adjusted hazard ratio = 1.66, p <0.001). Potential factors to the bidirectional interaction include shared pathophysiological mechanisms such as chronic inflammation and dysfunction of the hypothalamic-pituitary-adrenal axis. Conclusion: This cohort analysis supports that diabetes and major depressive disorder are linked bidirectionally. The results indicate a correlation between diabetes and subsequent development of MDD. This association could be the result of comparable pathophysiological processes. These results highlight interdisciplinary healthcare methods’ significance in managing disorders and mitigating their adverse health effects. Additional research is required to determine causal factors and design effective preventative and therapeutic strategies.
Abstract (English)
Background: Diabetes Mellitus (DM) and Major Depressive Disorder (MDD) are prevalent, chronic conditions that frequently occur together. The mutual influence between these disorders has significant implications for healthcare administration. This study aims to investigate the retrospective biological and psychosocial aspects and the epidemiological association between type 2 diabetes and major depressive disorder. Methods: 500 people aged 18 to 65 participated in a retrospective cohort study. Group A consisted of 250 people with a confirmed diagnosis of DM, while Group B consisted of 250 people with a confirmed diagnosis of MDD. Participants initially completed questionnaires regarding their demographics, medical histories, and mental health. Over five years, Group A participants were monitored for the development of MDD, while Group B participants were observed for the development of diabetes. Regression models and survival analyses were utilised to quantify the strength and direction of the association. Results: The correlation between diabetes and MDDare shown to go both ways in the cohort study. During the observation period, 65 people in Group A (26% of the total) were diagnosed with MDD. Participants with DM had a significantly increased risk of acquiring MDD compared to the general population (adjusted hazard ratio = 1.82, p< 0.001). During the observation period, Type 2 diabetes occurred in 53 people in Group B, or 21 per cent. Individuals with MDD were more likely to develop DM than those without MDD (adjusted hazard ratio = 1.66, p <0.001). Potential factors to the bidirectional interaction include shared pathophysiological mechanisms such as chronic inflammation and dysfunction of the hypothalamic-pituitary-adrenal axis. Conclusion: This cohort analysis supports that diabetes and major depressive disorder are linked bidirectionally. The results indicate a correlation between diabetes and subsequent development of MDD. This association could be the result of comparable pathophysiological processes. These results highlight interdisciplinary healthcare methods’ significance in managing disorders and mitigating their adverse health effects. Additional research is required to determine causal factors and design effective preventative and therapeutic strategies.
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IJPCR,Vol15,Issue7,Article43.pdf
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Additional details
Dates
- Accepted
-
2023-05-25
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue7,Article43.pdf
- Development Status
- Active
References
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