Evaluation of Anaesthetic Effects of Intrathecal 2-Chloroprocaine with or Without Fentanyl in Perianal Surgery:A Prospective and Randomized Study
Authors/Creators
- 1. Junior resident, Department of Anaesthesiology, RNT Medical College, Udaipur
- 2. Associate Professor, Department of Anaesthesiology, RNT Medical College, Udaipur
- 3. Associate Professor, Department of Anaesthesiology, Pacific Medical College and Hospital, Udaipur
- 4. Senior resident, Department of Emergency Medicine, Govt Medical College, Chittorgarh
Description
Introduction: Spinal anaesthesia is reliable and safe technique for perianal surgeries. 2-Chloroprocaine has a rapid onset and short duration of action and less systemic toxicity. The primary goal of ambulatory anaesthesia is rapid recovery leading to early patient discharge with minimal side effects. Aim: This study was aimed to evaluate the effectiveness of 2-chloroprocaine with or without fentanyl in perianal surgeries in terms of block characteristics as primary objective and to note haemodynamics and any side effects as secondary objective. Study design: A prospective, randomized, double blind interventional study. Methods: Sixty adult patients of 18-60 years, of either sex, ASA grade I or II posted for perianal surgeries under spinal anaesthesia were randomized into two groups of 30 each, in which one group (CF) received1% 2-chloroprocaine 3 ml (30mg) with fentanyl 0.5ml (25mcg) and other group (CS) received 1% 2-chloroprocaine 3ml (30mg) with normal saline 0.5ml. Results: The mean time to peak sensory level in Group CF was 8.20±0.96 min and in Group CS, it was 8.66±0.95 min (P = 0.065). The mean duration of sensory block in Group CF was 96.20±10.30 min and in Group CS, it was 90.60±10.92 min (P = 0.045). The mean duration of motor block in Group CF was 90.47±8.67 min and in Group CS, it was 88.43±8.67 min (P= 0.31). The mean duration of analgesia in Group CF was 117.60±11.54 min and in Group CS, it was 111.28±11.66 min (P = 0.039). Conclusion: Addition of fentanyl 25 mcg as an adjuvant to 2-chloroprocaine (30 mg) resulted in marginal but statistically significant prolongation of sensory block duration and time to rescue analgesia in patient undergoing perianal surgery under spinal anaesthesia.
Abstract (English)
Introduction: Spinal anaesthesia is reliable and safe technique for perianal surgeries. 2-Chloroprocaine has a rapid onset and short duration of action and less systemic toxicity. The primary goal of ambulatory anaesthesia is rapid recovery leading to early patient discharge with minimal side effects. Aim: This study was aimed to evaluate the effectiveness of 2-chloroprocaine with or without fentanyl in perianal surgeries in terms of block characteristics as primary objective and to note haemodynamics and any side effects as secondary objective. Study design: A prospective, randomized, double blind interventional study. Methods: Sixty adult patients of 18-60 years, of either sex, ASA grade I or II posted for perianal surgeries under spinal anaesthesia were randomized into two groups of 30 each, in which one group (CF) received1% 2-chloroprocaine 3 ml (30mg) with fentanyl 0.5ml (25mcg) and other group (CS) received 1% 2-chloroprocaine 3ml (30mg) with normal saline 0.5ml. Results: The mean time to peak sensory level in Group CF was 8.20±0.96 min and in Group CS, it was 8.66±0.95 min (P = 0.065). The mean duration of sensory block in Group CF was 96.20±10.30 min and in Group CS, it was 90.60±10.92 min (P = 0.045). The mean duration of motor block in Group CF was 90.47±8.67 min and in Group CS, it was 88.43±8.67 min (P= 0.31). The mean duration of analgesia in Group CF was 117.60±11.54 min and in Group CS, it was 111.28±11.66 min (P = 0.039). Conclusion: Addition of fentanyl 25 mcg as an adjuvant to 2-chloroprocaine (30 mg) resulted in marginal but statistically significant prolongation of sensory block duration and time to rescue analgesia in patient undergoing perianal surgery under spinal anaesthesia.
Files
IJPCR,Vol15,Issue7,Article30.pdf
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Additional details
Dates
- Accepted
-
2023-05-05
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue7,Article30.pdf
- Development Status
- Active
References
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