Comparative Study of Short-Term and Long-Term Use of Prophylactic Antibiotics in Post-Operative Caesarean Section

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Abstract (English)

Abstract
Aim: The aim of the study was to evaluate the effectiveness & reduce the relative efficacy of short-term vs
long-term course of prophylactic antibiotics on post-operative caesarean section wound.
Material & Methods: A Prospective observational and analytical study was conducted at “Patna Medical
College and Hospital, Patna, Bihar, India in the Department of Obstetrics and Gynaecology included 400
participants randomized into two groups. Each group consisting of 200 each. The participants were selected
based on the inclusion and exclusion criteria. in between Dec 2019 to Dec 2021 for a period of two years. The
women were explained about the nature of the study, the study outcome and written informed consent was
obtained. Post operatively both the groups of patients were monitored for infectious morbidity as febrile
morbidity, wound induration, wound discharge, wound gaping and any abnormal vaginal discharge.
Results: A total of 400 patients were recruited for the study with 200 patients in group 1 and 200 patients in
group 2. The result showed that the total patients recruited for the study in group 1 is 200 patients consisting of
129 multi para (64.5%) and 71 primi para (35.5%), and 200 patients were recruited in group 2 which consists of
139 (69.5%) multi para and 61 (30.5%) primi para. In group 1 the Primary LSCS rate was 57.5% (115),
Previous 2 LSCS 11.5% (23) and Previous LSCS was 31% (62). In group 2 the Primary LSCS rate was 58.5%
(117), Previous 2 LSCS 14.5% (29) and Previous LSCS was 27% (54).
Conclusion: The short course (48hrs) of antibiotics that is equally efficacious as the long course (5 or more
days) of antibiotics. There was no significant the difference noted between the two groups compared in terms of
febrile morbidity, wound induration, serous wound discharge, and purulent wound discharge wound gaping or
abnormal vaginal discharge