The ribosome lowers the entropic penalty of protein folding

This work was supported by a Wellcome Trust Investigator Award (to J.C., 206409/Z/17/Z) and by the Francis Crick Institute through provision of access to the MRC Biomedical NMR Centre. The Francis Crick Institute receives its core funding from Cancer Research UK (FC001029), the UK Medical Research Council (FC001029) and the Wellcome Trust (FC001029). This project made use of time on HPC resources on Archer2 (ARCHER2 UK National Supercomputing service, https://www.archer2.ac.uk) granted via the UK High-End Computing Consortium for Biomolecular Simulation, HECBioSim (http://hecbiosim.ac.uk), supported by EPSRC (grant no. EP/R029407/1 and EP/X035603/1). We also acknowledge the EuroHPC Joint Undertaking for awarding this project access to the EuroHPC supercomputer LUMI, hosted by CSC (Finland) and the LUMI consortium through a EuroHPC Regular Access call and the Baskerville Tier 2 HPC service (https://www.baskerville.ac.uk/). Baskerville was funded by the EPSRC and UKRI through the World Class Labs scheme (EP/T022221/1) and the Digital Research Infrastructure programme (EP/W032244/1) and is operated by Advanced Research Computing at the University of Birmingham. We additionally acknowledge the use of the UCL Myriad and Kathleen High Performance Computing Facility (Myriad@UCL and Kathleen@UCL), and associated support services, in the completion of this work.