Effect of Intravenous Tranexamic Acid on Blood Loss during and After Caeserean Delivery: A Prospective Randomised Study
Authors/Creators
- 1. PG-Student, Department of Obstetrics and Gynaecology, Yashoda Multi-speciality Hospital, Somajiguda, Hyderabad, India
- 2. Consultant, Department of Obstetrics and Gynaecology, Yashoda Multi-speciality Hospital, Somajiguda, Hyderabad, India
Description
Abstract
Aim: The aim of the present study was to document the efficacy of intravenous (IV) tranexamic acid in reducing
blood loss during and after caesarean section (CS)
Material & methods: The present study was conducted in the Department of Obstetrics and Gynaecology for
one year. 100 women were included in the study. Patients were divided into two groups: Control group A: (n=50)
IV placebo i.e.10 ml of Ringer Lactate and Study Group (B):(n=50) IV intravenous tranexamic acid 1g (10 ml).
Results: The mean age, weight and height of both the groups were not statistical significant. Majority of the
respondents were parity 0, 33 (66%), followed by gravida 1, 28 (56%), and gravida 2, 20 (40%). The most common
indication for LSCS was CPD 27 (27%), followed by Post-dated pregnancy with high floating head 25 (25%),
Previous one/two caesarean section 20 (20%). The mean total blood loss was 499.75 ± 111.20 ml and 690.85 ±
198.41 ml in TXA and the control group respectively. The result was found to be significant (p=0.001).
Tranexamic acid significantly reduces bleeding from the time of delivery of placenta to 2 hours postpartum.
According to post-operative vitals, the mean pulse rate showed statistical significant difference. APGAR scores
did not show any significant difference in both the groups. The most common side effect was nausea followed by
vomiting in both the groups which was non significant
Conclusion: Pre-operative IV tranexamic acid significantly reduced blood loss during & after elective CS without
any significant adverse effects.
Abstract (English)
Abstract
Aim: The aim of the present study was to document the efficacy of intravenous (IV) tranexamic acid in reducing
blood loss during and after caesarean section (CS)
Material & methods: The present study was conducted in the Department of Obstetrics and Gynaecology for
one year. 100 women were included in the study. Patients were divided into two groups: Control group A: (n=50)
IV placebo i.e.10 ml of Ringer Lactate and Study Group (B):(n=50) IV intravenous tranexamic acid 1g (10 ml).
Results: The mean age, weight and height of both the groups were not statistical significant. Majority of the
respondents were parity 0, 33 (66%), followed by gravida 1, 28 (56%), and gravida 2, 20 (40%). The most common
indication for LSCS was CPD 27 (27%), followed by Post-dated pregnancy with high floating head 25 (25%),
Previous one/two caesarean section 20 (20%). The mean total blood loss was 499.75 ± 111.20 ml and 690.85 ±
198.41 ml in TXA and the control group respectively. The result was found to be significant (p=0.001).
Tranexamic acid significantly reduces bleeding from the time of delivery of placenta to 2 hours postpartum.
According to post-operative vitals, the mean pulse rate showed statistical significant difference. APGAR scores
did not show any significant difference in both the groups. The most common side effect was nausea followed by
vomiting in both the groups which was non significant
Conclusion: Pre-operative IV tranexamic acid significantly reduced blood loss during & after elective CS without
any significant adverse effects.
Files
IJCPR,Vol15,Issue11,Article134.pdf
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