Prospective, Observational Study to Investigate the Renal Function in Patients with Acute Stroke and its Relationship with in-Hospital Mortality

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Abstract (English)

Abstract
Aim: The aim of the present study was to investigate the renal function in patients with acute stroke and its
relationship with in-hospital mortality.
Methods: The present study was a prospective, observational study conducted at department of Medicine for the
period of 2 years. 200 patients were considered for present study.
Results: 80% were from group A while 20% were from group B. Most patients were from >65 years age group,
male, BMI<30. Hypertension, smoking, diabetes mellitus, cardiovascular disease, alcohol consumption,
dyslipidemia, previous history of stroke/TIA were common risk factors in both groups. On admission most
patients had GCS score 5-13. 104 (65%) patients had ischemic stroke, while 48 (30%) had hemorrhagic stroke.
We noted mortality within 30 days in 24 (15%) patients. We distributed patients according to Serum Creatinine
concentration at time of presentation, most patients had serum creatinine in the range of 98-118 (32%) followed
by 82-97 (30%). Maximum mortality was noted in >119 (40%) followed by 98-118 (35%) serum creatinine group.
We distributed patients according to blood urea concentration at time of presentation, most patients had blood
urea in the range of 6.8-8.9 (40%) followed by 5.3-6.7 (25%). Maximum mortality was noted in >9 (45%) followed
by 6.8-8.9 (30%) blood urea group.
We noted that age > 65 years, GCS score > 10 at the time of admission, smoking, diabetes mellitus and aspiration
pneumonitis were predictors of death in stroke patients.
Conclusion: The severity of impaired kidney function in patients hospitalized with acute stroke is associated with
increased mortality independent of age, sex, and major comorbidities. Unrecognized renal insufficiency noted by
low eGFR is common in patients with acute stroke and is associated with higher mortality adverse short-term
outcomes.