A Prospective Etiological Assessment of Hypersegmented Neutrophils in Peripheral Blood Smear
Authors/Creators
- 1. M.D. (Pathology) Tutor, Department of Pathology, Nalanda Medical
- 2. Professor, Department of Pathology, NMCH, Patna, Bihar, India.
Description
Background: Hypersegmented Neutrophils Are Usually Associated With Deficiency Of Or Failure To Utilize Cobalamin Or Folate And Impaired DNA Synthesis Is The Accepted Mechanism For The Morphological Changes Seen In Megaloblastosis. Material & Methods: This Is A Prospective Study Conducted In Department Of Pathology, NMCH, Patna, Bihar, India, From April 2018 To March 2019. Results: Cases Were Further Analyzed For Associated Peripheral Smear Picture. Although Major Cases Were Contributed By Macrocytic Anemia, 46 Cases Were Having Microcytic Hypochromic Anemia. Out Of The 120 Cases, Only 4 Had Thrombocytopenia. 91 Cases Had Platelet Count In The Normal Range. Conclusion: The Present Study Indicates That Other Than The Already Established Causes Of Neutrophil Hyper Segmentation, Microcytic Hypochromic Anemia, Myelodysplastic Syndromes And Inflammatory Conditions Also Can Cause Hypersegmented Neutrophils In Peripheral Smears.
Abstract (English)
Background: Hypersegmented Neutrophils Are Usually Associated With Deficiency Of Or Failure To Utilize Cobalamin Or Folate And Impaired DNA Synthesis Is The Accepted Mechanism For The Morphological Changes Seen In Megaloblastosis. Material & Methods: This Is A Prospective Study Conducted In Department Of Pathology, NMCH, Patna, Bihar, India, From April 2018 To March 2019. Results: Cases Were Further Analyzed For Associated Peripheral Smear Picture. Although Major Cases Were Contributed By Macrocytic Anemia, 46 Cases Were Having Microcytic Hypochromic Anemia. Out Of The 120 Cases, Only 4 Had Thrombocytopenia. 91 Cases Had Platelet Count In The Normal Range. Conclusion: The Present Study Indicates That Other Than The Already Established Causes Of Neutrophil Hyper Segmentation, Microcytic Hypochromic Anemia, Myelodysplastic Syndromes And Inflammatory Conditions Also Can Cause Hypersegmented Neutrophils In Peripheral Smears.
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IJTPR,Vol12,Issue8,Article39.pdf
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Additional details
Dates
- Accepted
-
2022-08-14
Software
References
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