A Retrospective Cross Sectional Analysis of Drug Induced Diseases in A Tertiary Care Teaching Hospital Western Rajasthan
Authors/Creators
- 1. Final Year Resident, Department of Pharmacology, JLN Medical College, Ajmer (Rajasthan) India
- 2. Associate Professor, Department of Pharmacology, Government Medical College, Kota (Rajasthan) India
- 3. Assistant Professor, Department of General Medicine, Government Medical College, Kota (Rajasthan) India
- 4. Senior Professor, Department of Pharmacology, JLN Medical College, Ajmer (Rajasthan) India
Description
Introduction: Adverse drug reaction (ADR) has been implicated as a leading cause of considerable morbidity and mortality worldwide. The prevalence rate of ADRs has been reported to range from 0.16 to 15.7 per cent. Drug induced diseases (DIDs) are well known but least studies. Data on DIDs from India are not available. Hence, this retrospective study was conducted. Material& Methods: The present study was conducted in the department of Pharmacology, Government Medical College Kota. It was a cross sectional retrospective observational study carried out over a period of one year from Jan 2022 to December 2022. Data were collected to evaluate the prevalence and profile of DIDs in Adverse Drug Reaction Monitoring (ADRM) Centre, working under Pharmacovigilance Programme of India (PvPI) in a tertiary care teaching hospital from north India (Government Medical College, Kota) using suspected drug reactions monitoring data collection form used under PvPI. Results: In this study, indoor & outdoor patients’ were analyzed and patient reported experience adverse drug reaction on the basis inclusion and exclusion criteria. The total number of ADR events reported during the one year study period was 1385 and out of these 546 (39.42%) were the drug induced disease rate. Among them 243(44.5%) were male and 303(55.5%) were female. The maximum number of patients were found to be in geriatric age group 301(55%); followed by adult 201 (36.8%) and paediatric population 44(8.05%). Mean duration of appearance of DIDs was 28.05±9 days. Conclusion: Our study concluded that, the total number of reported ADR events, Drug Induce disease rate found high. The maximum number of patients was found to be in geriatric age group. In our study, Maximum ADR events were probable followed by possible according to causality WHO-UMC scale. Our findings show that DIDs are significant health problem in our country, which need more attention.
Abstract (English)
Introduction: Adverse drug reaction (ADR) has been implicated as a leading cause of considerable morbidity and mortality worldwide. The prevalence rate of ADRs has been reported to range from 0.16 to 15.7 per cent. Drug induced diseases (DIDs) are well known but least studies. Data on DIDs from India are not available. Hence, this retrospective study was conducted. Material& Methods: The present study was conducted in the department of Pharmacology, Government Medical College Kota. It was a cross sectional retrospective observational study carried out over a period of one year from Jan 2022 to December 2022. Data were collected to evaluate the prevalence and profile of DIDs in Adverse Drug Reaction Monitoring (ADRM) Centre, working under Pharmacovigilance Programme of India (PvPI) in a tertiary care teaching hospital from north India (Government Medical College, Kota) using suspected drug reactions monitoring data collection form used under PvPI. Results: In this study, indoor & outdoor patients’ were analyzed and patient reported experience adverse drug reaction on the basis inclusion and exclusion criteria. The total number of ADR events reported during the one year study period was 1385 and out of these 546 (39.42%) were the drug induced disease rate. Among them 243(44.5%) were male and 303(55.5%) were female. The maximum number of patients were found to be in geriatric age group 301(55%); followed by adult 201 (36.8%) and paediatric population 44(8.05%). Mean duration of appearance of DIDs was 28.05±9 days. Conclusion: Our study concluded that, the total number of reported ADR events, Drug Induce disease rate found high. The maximum number of patients was found to be in geriatric age group. In our study, Maximum ADR events were probable followed by possible according to causality WHO-UMC scale. Our findings show that DIDs are significant health problem in our country, which need more attention.
Files
IJPCR,Vol15,Issue7,Article20.pdf
Files
(340.1 kB)
| Name | Size | Download all |
|---|---|---|
|
md5:deb6d9cf562c8ff68dc3d0489bdfe7bb
|
340.1 kB | Preview Download |
Additional details
Dates
- Accepted
-
2023-06-30
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue7,Article20.pdf
- Development Status
- Active
References
- 1. Kongkaew C, Noyce PR, Asheroft DM. Hospital admission associated with adverse drug reaction: a systematic review of prospective observational studies. Ann Pharmacother 2008; 42 : 1017-25. 2. De Paepe P, Petrovic M, Outtier L, Van Maele G, Buylaert W. Drug interactions and adverse drug reactions in the older patients admitted to the emergency department. Acta Clin Belg 2013; 68: 15-21. 3. Pérez Menéndez-Conde C, Bermejo Vicedo T, Delgado Silveira E, Carretero Accame E. Adverse drug reactions which provoke hospital admission. Farm Hosp 2011; 35 : 236-43. 4. Permpongkosol S. Iatrogenic disease in the elderly: risk factors, consequences, and prevention. Clin Interv Aging 2011; 6 : 77-82. 5. Ahern F, Sahm LJ, Lynch D, McCarthy S. Determining the frequency and preventability of adverse drug reaction-related admissions to an Irish University Hospital: a cross-sectional study. Emerg Med J 2014; 31 : 24-9. 6. Atiqi R, van Bommel E, Cleophas TJ, Zwinderman AH. Prevalence of iatrogenic admissions to the Departments of Medicine/Cardiology/ Pulmonology in a 1,250 bed general hospital. Int J Clin Pharmacol Ther 2010; 48 : 517-24. 7. Zopf Y, Rabe C, Neubert A, Hahn EG, Dormann H. Risk factors associated with adverse drug reactions following hospital admission: a prospective analysis of 907 patients in two German university hospitals. Drug Saf 2008; 31 : 789- 98. 8. Brvar M, Fokter N, Bunc M, Mozina M. The frequency of adverse drug reaction related admissions according to method of detection, admission urgency and medical department specialty. BMC Clin Pharmacol 2009; 9 : 8. 9. de la Sierra A, Cardellach F, Cobo E, Bové A, Roigé M, Santos MJ, et al. Iatrogenic illness in a department of general internal medicine: a prospective study. Mt Sinai J Med 1989; 56 : 267-71 10. Thiessard F, Roux E, Miremont-Salamé G, Fourrier-Réglat A, Haramburu F, Tubert-Bitter P, et al. Trends in spontaneous adverse drug reaction reports to the French pharmacovigilance system (1986-2001). Drug Saf 2005; 28 : 731-40. 11. Anwikar SR, Bandekar MS, Smrati B, Pazare AP, Tatke PA, Kshirsagar NA. HAART induced adverse drug reactions: a retrospective analysis at a tertiary referral health care center in India. Int J Risk Saf Med 2011; 23 : 163-9. 12. Tariq S, Khan TS, Malik S, Anwar MS, Rashid A. Frequency of anti-tuberculous therapyinduced hepatotoxicity in patients and their outcome. J Ayub Med Coll Abbottabad 2009; 21 : 50-52. 13. Park SH, Ishino R. Liver injury associated with antidepressants. Curr Drug Saf 2013; 8: 207-23. 14. Kennelly C, Esaian D. Drug-induced cardiovascular adverse events in the intensive care unit. Crit Care Nurs Q 2013; 36: 323-34. 15. Garratty G. Drug-induced immune hemolytic anemia. Hematol Am Soc Hematol Educ Program 2009; 1 : 73 9. 16. Garratty G. Immune hemolytic anemia associated with drug therapy. Blood Rev 2010; 24:143-50.