Antibiotic Resistance Pattern in MRSA: Study in Central India
Authors/Creators
- 1. Demonstrator, Department of Microbiology, Govt. Bundelkhand Medical College, Sagar (M.P)
- 2. Assistant Professor, Department of Medicine, Govt. Bundelkhand Medical College, Sagar (M.P)
- 3. Assistant Professor, Department of Pediatrics, Govt. Bundelkhand Medical College, Sagar (M.P)
- 4. Associate Professor, Department of Orthopaedics, Govt. Bundelkhand Medical College, Sagar (M.P)
- 5. Professor, Department of Microbiology, Govt. Bundelkhand Medical College, Sagar (M.P)
Description
Abstract
Introduction:- Infections caused by MRSA are worldwide, detecting the mecA gene or its product by PCR is
recognized as a gold standard for detection of MRSA. In resource limited clinical settings phenotypic method
which is simple, rapid, accurate and cost effective is required. Cefoxitin disc diffusion is considered as surrogate
marker for mecA gene, and could be considered as gold standard for MR isolates. MRSA infection is of concern
because it is resistant to a number of widely used antibiotics. Treatment options for MRSA are limited and less
effective, than options available for susceptible S. aureus infections leading to increased morbidity and mortality
in hospitalized patients. To control MRSA in hospitals, correct antibiotic treatment in infected patients is required
and prevent their spread.
Object: This study is conducted to know the resistance pattern of various antibiotics in Methicillin-resistant
Staphylococcus aureus(MRSA)
Material and Methods:
Type of study: Cross-sectional prospective analytical study
Study time: November 2012 to April 2014
Sample size: Total of 174 S. aureus isolated from non-repetitive clinical samples from IPD and OPD of tertiary
care hospital in Bhopal.
Result: 174 Staphylococcus aureus strains isolated from the non-repetitive clinical samples were processed for
MRSA identification. Out of 174 S. aureus isolates 69(39.65%) were found to be MRSA by cefoxitin disc
diffusion test and rest 105 strains were MSSA. Among MRSA more than 70% resistance is for Ampicillin and
Erythromycin and low resistance was for Netilmycin 27.53%, Doxycycline 24.63% and 5.79% for Linezolid and
no resistance for Teicoplanin and Vancomycin.
Discussion: Multidrug resistance among S. aureus is a potential threat for the health care settings. Prolonged
hospitalization and antibiotic therapy especially with β-lactam antibiotics predispose patients to the acquisition of
MDR. To control and prevent the spread of MRSA in hospitals, correct antibiotic treatment in infected patients
is required and ad mistered.
Abstract (English)
Abstract
Introduction:- Infections caused by MRSA are worldwide, detecting the mecA gene or its product by PCR is
recognized as a gold standard for detection of MRSA. In resource limited clinical settings phenotypic method
which is simple, rapid, accurate and cost effective is required. Cefoxitin disc diffusion is considered as surrogate
marker for mecA gene, and could be considered as gold standard for MR isolates. MRSA infection is of concern
because it is resistant to a number of widely used antibiotics. Treatment options for MRSA are limited and less
effective, than options available for susceptible S. aureus infections leading to increased morbidity and mortality
in hospitalized patients. To control MRSA in hospitals, correct antibiotic treatment in infected patients is required
and prevent their spread.
Object: This study is conducted to know the resistance pattern of various antibiotics in Methicillin-resistant
Staphylococcus aureus(MRSA)
Material and Methods:
Type of study: Cross-sectional prospective analytical study
Study time: November 2012 to April 2014
Sample size: Total of 174 S. aureus isolated from non-repetitive clinical samples from IPD and OPD of tertiary
care hospital in Bhopal.
Result: 174 Staphylococcus aureus strains isolated from the non-repetitive clinical samples were processed for
MRSA identification. Out of 174 S. aureus isolates 69(39.65%) were found to be MRSA by cefoxitin disc
diffusion test and rest 105 strains were MSSA. Among MRSA more than 70% resistance is for Ampicillin and
Erythromycin and low resistance was for Netilmycin 27.53%, Doxycycline 24.63% and 5.79% for Linezolid and
no resistance for Teicoplanin and Vancomycin.
Discussion: Multidrug resistance among S. aureus is a potential threat for the health care settings. Prolonged
hospitalization and antibiotic therapy especially with β-lactam antibiotics predispose patients to the acquisition of
MDR. To control and prevent the spread of MRSA in hospitals, correct antibiotic treatment in infected patients
is required and ad mistered.
Files
IJCPR,Vol15,Issue11,Article7.pdf
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Additional details
Dates
- Accepted
-
2023-10-18