Correlation between Microalbuminuria and Coronary Artery Diseases (CAD) In Type-2 Diabetes Mellitus, a Study in a Tertiary Care Hospital in Western India
Authors/Creators
- 1. Assistant Professor, Department of General Medicine, National Institute of Medical Sciences and Research, Jaipur Rajasthan
- 2. Senior Demonstrator, Department of Pathology, Sawai Man Singh Medical College, Jaipur Rajasthan
Description
Introduction: Diabetes mellitus, a multi-systemic metabolic disorder, is one of the leading causes of mortality and morbidity worldwide. Coronary heart disease is the main cause of premature death in type-2 diabetes. Early diagnosis of Microalbuminuria with a direct correlation with intima-medial thickening will predict the degree of atherosclerosis, as atherosclerosis is the major cause of mortality and morbidity in these patients. Aim & Objective: To determine the correlation between Microalbuminuria and Coronary Artery Disease (CAD) in type -2 Diabetes Mellitus patients. To study statistical significance of various parameters in our study population. Materials & Methods: The present study include total three hundred patients in the Department of Medicine, National Institute of Medical Science and Research, Jaipur, Rajasthan a tertiary care hospital from June 2022 to May 2023. Biochemical and clinical risk factors assessed for Diabetes Mallitus and coronary artery disease. Microalbuminuria is defined as excretion of albumin in urine in the range of 20 to 200μg/min. (30-300mg/day). Results: Case group are Type -2 Diabetes Mellitus with Microalbuminuria and control group are Type 2 Diabetes Mellitus without Microalbuminuria. The mean age in the case and control group for males were 58.01 and 58.10 years respectively, while for females the values were 57.66 and 56.55 years respectively. The mean age±SD of all subjects of the case and control group were 57.9±8.18 and 57.39±7.75 years respectively. There is a significant association between Age and CAD in both case and control group (x2=33.64, P <0.001 HS). CAD+ patients are Highly Significant higher (P<.001) in more than 50 years age group in comparison to less than 50 years age group (x²= 23.66 P <0.001 HS). In >50 year age group CAD patients are highly Significant higher in case group in comparison to control (x² = 29.84 P <0.001). CAD + Cases are Highly Significantly higher in males in comparison to females (x²=41.45, P<0.001 HS). CAD in males are Highly Significantly higher in case group in comparison to control. (x²=35.67 P <0.001). In case group 90.65% of male and in control group 50% male had CAD. In case group 46.15% of female and in control group 28.81% of female had CAD. Conclusions: There is an association between age and CAD in both microalbuminuric and nonmicroalbuminuric Diabetes Mellitus patients but more in microalbuminuric Diabetes Mellitus case. Risk of CAD is higher in both sexes in microalbuminuric Diabetes Mellitus subjects as compared to nonmicroalbuminuric Diabetes Mellitus patients. Microalbuminuria showed a positive correlation with coronary artery disease (CAD) in type -2 Diabetes Mellitus subjects. In type -2 Diabetes Mellitus an association of Microalbuminuria had a more significant association with CAD as compared to subjects of type 2 Diabetes Mellitus without Microalbuminuria.
Abstract (English)
Introduction: Diabetes mellitus, a multi-systemic metabolic disorder, is one of the leading causes of mortality and morbidity worldwide. Coronary heart disease is the main cause of premature death in type-2 diabetes. Early diagnosis of Microalbuminuria with a direct correlation with intima-medial thickening will predict the degree of atherosclerosis, as atherosclerosis is the major cause of mortality and morbidity in these patients. Aim & Objective: To determine the correlation between Microalbuminuria and Coronary Artery Disease (CAD) in type -2 Diabetes Mellitus patients. To study statistical significance of various parameters in our study population. Materials & Methods: The present study include total three hundred patients in the Department of Medicine, National Institute of Medical Science and Research, Jaipur, Rajasthan a tertiary care hospital from June 2022 to May 2023. Biochemical and clinical risk factors assessed for Diabetes Mallitus and coronary artery disease. Microalbuminuria is defined as excretion of albumin in urine in the range of 20 to 200μg/min. (30-300mg/day). Results: Case group are Type -2 Diabetes Mellitus with Microalbuminuria and control group are Type 2 Diabetes Mellitus without Microalbuminuria. The mean age in the case and control group for males were 58.01 and 58.10 years respectively, while for females the values were 57.66 and 56.55 years respectively. The mean age±SD of all subjects of the case and control group were 57.9±8.18 and 57.39±7.75 years respectively. There is a significant association between Age and CAD in both case and control group (x2=33.64, P <0.001 HS). CAD+ patients are Highly Significant higher (P<.001) in more than 50 years age group in comparison to less than 50 years age group (x²= 23.66 P <0.001 HS). In >50 year age group CAD patients are highly Significant higher in case group in comparison to control (x² = 29.84 P <0.001). CAD + Cases are Highly Significantly higher in males in comparison to females (x²=41.45, P<0.001 HS). CAD in males are Highly Significantly higher in case group in comparison to control. (x²=35.67 P <0.001). In case group 90.65% of male and in control group 50% male had CAD. In case group 46.15% of female and in control group 28.81% of female had CAD. Conclusions: There is an association between age and CAD in both microalbuminuric and nonmicroalbuminuric Diabetes Mellitus patients but more in microalbuminuric Diabetes Mellitus case. Risk of CAD is higher in both sexes in microalbuminuric Diabetes Mellitus subjects as compared to nonmicroalbuminuric Diabetes Mellitus patients. Microalbuminuria showed a positive correlation with coronary artery disease (CAD) in type -2 Diabetes Mellitus subjects. In type -2 Diabetes Mellitus an association of Microalbuminuria had a more significant association with CAD as compared to subjects of type 2 Diabetes Mellitus without Microalbuminuria.
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IJPCR,Vol15,Issue8,Article182.pdf
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Additional details
Dates
- Accepted
-
2023-05-05
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue8,Article182.pdf
- Development Status
- Active
References
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