EVALUATION OF ANTI-PARKINSON'S & ANTI-ALZHEIMER'S ACTIVITIES OF MURRAYA KOENIGII & CYMBOPOGON CITRATUS FOR SYNERGISTIC ACTION ON HALOPERIDOL &ETHANOL INDUCED NEURODEGENERATIVE DISEASES IN MALE SPRAGUE-DAWELY RATS

Background:

The aim of the present study is to evaluate the pharmacological screening of Murraya koenigii and Cymbopogon citratus for synergistic activity against neurodegenerative disorders in rodents.

Objectives:

To screen the combined effect of Murraya koenigii and Cymbopogon citratus extracts against Ethanol induced Cognitive impairment (Morris water maze (MWM) and Actophotometer) [For Learning and memory activity in Alzheimer’s disease and Locomotoractivity in Parkinson’s disease].  

Materials and methods: To screen the Synergistic activity of Murraya koenigii and Cymbopogon citratus extracts against haloperidol induced catatonia model in SD rats (Anti-parkinsonism/ catatonia activity), ethanol- induced cognitive impairment (learning and memory activity in Alzheimer's disease).

Results: For anti-parkinsonism activity scoring of Catalepsy by using motor activity by using actophotometer where as learning and memory activity was performed to evaluate the effect of Synergistic activity of Murraya koenigii and Cymbopogon citratus on alzeimer’s disease  by  using the Morris water maze (MWM)  by comparing with the control group.

Keywords: Murraya koenigii and Cymbopogon citratus, neurodegenerative disorders, anti-parkinsonism activity, learning and memory activity in alzeimer’s disease & histopathological studies.