To Evaluate the Prognostic Value of Some Serum Protein Fractions as Early Index of Clinical Recovery in Pulmonary Tuberculosis Subjects
Authors/Creators
- 1. Assistant Professor, Department of Pulmonary Medicine, Lord Buddha Koshi Medical College and Hospital, Saharsa, Bihar, India
Description
Aim: The aim of this study to evaluate the prognostic value of some serum protein fractions as early index of Clinical recovery in pulmonary tuberculosis subjects. Methods: This Interventional comparative study was done the Department of Pulmonary Medicine, Lord Buddha Koshi Medical College and Hospital, Saharsa ,Bihar, India for one year.A total of 100 subjects aged between 20 and 50 years were conveniently recruited for this study. 50 were clinically confirmed PTB subject with no HIV nor malaria co-infections. They were further sub-divided into TB subjects on ATT 25 and drug naive TB subjects 25. The remaining were 50 (25 females and 25 males) aged matched apparently healthy controls. Results: The results showed that BMI (kg/m2) in drug naive TB subjects (19.35 ± 2.75) and in the TB subjects on ATT (20.40 ± 2.90) was significantly lower when compared to control subjects (24.68 ± 3.15) (p=0.001). Similarly, waist and hip circumferences (cm) of the drug naive TB subjects (50.22 ± 1.44,70.68 ± 2.10) and the TB subjects on ATT (51.14 ± 2.98, 70.56 ± 2.75) were significantly lower when compared to control subjects (52.34 ± 4.56, 72.33 ± 3.54) (p=0.03 and 0.02). However, the mean value of WHR in drug naive TB subjects (0.72 ± 0.04) and in TB subjects on ATT (0.74 ± 0.05) were not statistically significant when compared to control subjects (0.73 ± 0.06) (p ¼ 0.27). In TB subjects on ATT, the mean (±SD) serum albumin (g/ dl) was (3.51 ± 1.57) and control subjects (3.83 ± 1.15) (p=0.108). In contrast, the drug naive TB subjects had a significantly lower mean serum albumin (2.88 ± 0.87) when compared with the control (3.83 ± 1.15) (p=0.001). Conclusion: We concluded that the BMI was found to be significantly lower in both drug naive PTB subjects and in PTB subjects on ATT when compared with the control subjects.
Abstract (English)
Aim: The aim of this study to evaluate the prognostic value of some serum protein fractions as early index of Clinical recovery in pulmonary tuberculosis subjects. Methods: This Interventional comparative study was done the Department of Pulmonary Medicine, Lord Buddha Koshi Medical College and Hospital, Saharsa ,Bihar, India for one year.A total of 100 subjects aged between 20 and 50 years were conveniently recruited for this study. 50 were clinically confirmed PTB subject with no HIV nor malaria co-infections. They were further sub-divided into TB subjects on ATT 25 and drug naive TB subjects 25. The remaining were 50 (25 females and 25 males) aged matched apparently healthy controls. Results: The results showed that BMI (kg/m2) in drug naive TB subjects (19.35 ± 2.75) and in the TB subjects on ATT (20.40 ± 2.90) was significantly lower when compared to control subjects (24.68 ± 3.15) (p=0.001). Similarly, waist and hip circumferences (cm) of the drug naive TB subjects (50.22 ± 1.44,70.68 ± 2.10) and the TB subjects on ATT (51.14 ± 2.98, 70.56 ± 2.75) were significantly lower when compared to control subjects (52.34 ± 4.56, 72.33 ± 3.54) (p=0.03 and 0.02). However, the mean value of WHR in drug naive TB subjects (0.72 ± 0.04) and in TB subjects on ATT (0.74 ± 0.05) were not statistically significant when compared to control subjects (0.73 ± 0.06) (p ¼ 0.27). In TB subjects on ATT, the mean (±SD) serum albumin (g/ dl) was (3.51 ± 1.57) and control subjects (3.83 ± 1.15) (p=0.108). In contrast, the drug naive TB subjects had a significantly lower mean serum albumin (2.88 ± 0.87) when compared with the control (3.83 ± 1.15) (p=0.001). Conclusion: We concluded that the BMI was found to be significantly lower in both drug naive PTB subjects and in PTB subjects on ATT when compared with the control subjects.
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Additional details
Dates
- Accepted
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2022-10-25
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References
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