Prospective Validation of Neutrophil-to-Lymphocyte Ratio as a Diagnostic and Management Adjunct in Acute Appendicitis
Authors/Creators
- 1. Ex Senior Resident, Government Medical College, Ratlam, (M.P.)
- 2. Senior Resident, MCh Plastic and Reconstructive Surgery, KGMU Lucknow (U.P.)
- 3. Professor & Head, Department of General Surgery, SAMC and PG Institute, Indore (M.P.)
- 4. Assistant Professor, Department of Forensic Medicine, Government Medical College, Ratlam (M.P.)
Description
Background: Acute appendicitis (AA) is one of the most common abdominal emergencies worldwide. Patients presenting with appendicitis may vary in severity. We conducted this study aiming top prospectively examine the role of NLR in assessing the severity of appendicitis, length of hospital stay, and rate of postoperative complications. We have 3 objectives namely to study neutrophil and lymphocyte count in appendicitis cases, to study various correlation and association regarding severity of appendicitis and neutrophil to lymphocyte ratio (NLR) & to study the validity of neutrophil to lymphocyte ratio (NLR) in predicting the severity, length of hospital stay and 30 day complication rate. The study was conducted in the department of general surgery at SAMC & PGI Indore (M.P.) from January 2018 to June 2019 on 100 patients which were selected according to inclusion and exclusion criteria Receiver Operating Characteristic (ROC) curve analysis was used for determining optimal cut-off value of NLR for complicated AA. Most of the patients with AA were in the age group of 20-29years with M:F ratio of 1.56:1. Mean NLR of patients treated surgically was raised (8.5±5.6) compared to conservatively treated patient (4.34). This value has sensitivity of 91% and specificity of 89% with Area Under Curve (AUC) of 0.941 with 95%confidence interval 0.895 to 0.987 and p value of<0.005.
Abstract (English)
Background: Acute appendicitis (AA) is one of the most common abdominal emergencies worldwide. Patients presenting with appendicitis may vary in severity. We conducted this study aiming top prospectively examine the role of NLR in assessing the severity of appendicitis, length of hospital stay, and rate of postoperative complications. We have 3 objectives namely to study neutrophil and lymphocyte count in appendicitis cases, to study various correlation and association regarding severity of appendicitis and neutrophil to lymphocyte ratio (NLR) & to study the validity of neutrophil to lymphocyte ratio (NLR) in predicting the severity, length of hospital stay and 30 day complication rate. The study was conducted in the department of general surgery at SAMC & PGI Indore (M.P.) from January 2018 to June 2019 on 100 patients which were selected according to inclusion and exclusion criteria Receiver Operating Characteristic (ROC) curve analysis was used for determining optimal cut-off value of NLR for complicated AA. Most of the patients with AA were in the age group of 20-29years with M:F ratio of 1.56:1. Mean NLR of patients treated surgically was raised (8.5±5.6) compared to conservatively treated patient (4.34). This value has sensitivity of 91% and specificity of 89% with Area Under Curve (AUC) of 0.941 with 95%confidence interval 0.895 to 0.987 and p value of<0.005.
Files
IJPCR,Vol15,Issue11,Article218.pdf
Files
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Additional details
Dates
- Accepted
-
2023-11-30
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue11,Article218.pdf
- Development Status
- Active
References
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