Clinical Profile of Laryngopharyngeal Reflux Disease and Effect of Treatment with Proton Pump Inhibitors
Authors/Creators
- 1. Senior Resident, Department of ENT, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, Bihar, India
- 2. Assistant Professor, Department of ENT, Indira Gandhi Institute of Medical Sciences, Sheikhpura, Patna, Bihar, India
Description
Background: Laryngopharyngeal reflux disease (LPRD) is a common problem all over world caused by the back-flow of stomach contents into the laryngopharynx. Symptomatology of laryngopharyngeal reflux includes chronic cough, hoarseness of voice, throat-clearing, globus sensation and difficulty in swallowing. LPRD is seen in about 10% of patients visiting outpatient departments of otolaryngology clinics and in more than 50% of patients presenting with changes in voice. LPRD can have association with sleep disorders, dental problems, food habits and various otolaryngological disorders. Gastric acid reflux with LPRD is considered causative factor for granulomas of the larynx and malignancy. Materials and Methods: This was a hospital based descriptive cross sectional study, conducted at the department of ENT at IGIMS, Patna. Patients having symptoms of Laryngopharyngeal reflux disease were included in the study. Data collection was done using clinical examination forms and written questionnaire and data was processed and analysed using SPSS. Results: This study was done on 292 subjects where 158 were males and 134 females. The mean age was 40.54 ± 12.68 years. Prevalence of LPRD was found to be 17.46% and there was slight male preponderance (18.35% in males, 16.41% in females). The common presentations were sensation of lump in throat, hoarseness of voice, sensation of mucus sticking in throat and urge to clear throat. Common findings were thick mucus, erythema of vocal cord, edema of vocal cord. Obesity, diabetes, hypertension, tobacco use, drinking alcohol, eating spicy foods were risk factors for LPRD. Patient’s positive for LPRD were treated with oral PPIs, life style and dietary modifications, and showed statistically significant improvement in symptoms and signs post treatment.
Abstract (English)
Background: Laryngopharyngeal reflux disease (LPRD) is a common problem all over world caused by the back-flow of stomach contents into the laryngopharynx. Symptomatology of laryngopharyngeal reflux includes chronic cough, hoarseness of voice, throat-clearing, globus sensation and difficulty in swallowing. LPRD is seen in about 10% of patients visiting outpatient departments of otolaryngology clinics and in more than 50% of patients presenting with changes in voice. LPRD can have association with sleep disorders, dental problems, food habits and various otolaryngological disorders. Gastric acid reflux with LPRD is considered causative factor for granulomas of the larynx and malignancy. Materials and Methods: This was a hospital based descriptive cross sectional study, conducted at the department of ENT at IGIMS, Patna. Patients having symptoms of Laryngopharyngeal reflux disease were included in the study. Data collection was done using clinical examination forms and written questionnaire and data was processed and analysed using SPSS. Results: This study was done on 292 subjects where 158 were males and 134 females. The mean age was 40.54 ± 12.68 years. Prevalence of LPRD was found to be 17.46% and there was slight male preponderance (18.35% in males, 16.41% in females). The common presentations were sensation of lump in throat, hoarseness of voice, sensation of mucus sticking in throat and urge to clear throat. Common findings were thick mucus, erythema of vocal cord, edema of vocal cord. Obesity, diabetes, hypertension, tobacco use, drinking alcohol, eating spicy foods were risk factors for LPRD. Patient’s positive for LPRD were treated with oral PPIs, life style and dietary modifications, and showed statistically significant improvement in symptoms and signs post treatment.
Files
IJPCR,Vol15,Issue11,Article113.pdf
Additional details
Dates
- Accepted
-
2023-10-30
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/15/IJPCR,Vol15,Issue11,Article113.pdf
- Development Status
- Active
References
- 1. Sataloff RT. Gastroesophageal reflux-related chronic laryngitis. Commentary. Arch Otolaryngol Head Neck Surg. 2010 Sep; 136(9):914-5. 2. Galli J, Cammarota G, Calo` L, et al. The role of acid and alkaline reflux in laryngeal squamous cell carcinoma. Laryn- goscope. 2002; 112:1861e1865. 3. Tae K, Jin BJ, Ji YB, Jeong JH, Cho SH, Lee SH. The role of laryngopharyngeal reflux as a risk factor in laryngeal cancer: a preliminary report. Clin Exp Otorhinolaryngol. 2011;4: 101e104. 4. Zucato B, Behlau MS. Laryngopharyngeal reflux symptoms index: relation with the main symptoms of gastroesophageal reflux, voice usage level and voice screening. Revista CEFAC. 2012; 14:1197e1203. 5. Ward PH, Hanson DG. Reflux as an etiological factor of carcinoma of the laryngopharynx. Laryngoscope. 1988; 98:1195e1199. 6. Taraszewska A. Risk factors for gastroesophageal reflux disease symptoms related to lifestyle and diet. Rocz Panstw Zakl Hig. 2021; 72(1):21-28. 7. Miko TL. Peptic (contact ulcer) granuloma of the larynx. J Clin Pathol. 1989; 42:800e804. 8. Koufman JA. The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury. Laryngoscope. 1991 Apr; 101(4 Pt 2 Suppl 53):1-78. 9. Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice 2002;16(02):274–277 10. Belafsky PC, PostmaGN, Koufman JA. The validity and reliability of the reflux finding score (RFS). Laryngoscope 2001; 111(08):1313–1317 11. Hamdan AL, Jaffal H, Btaiche R, et al. Laryngopharyngeal symptoms in patients with asthma: a cross-sectional controlled study. Clin Respir J. 2016; 10:40e47. 12. Campagnolo AM, Priston J, Thoen RH, Medeiros T, Assun¸ca˜o AR. Laryngopharyngeal reflux: diagnosis, treatment, and latest research. Int Arch Otorhinolaryngol. 2014; 18:184e191. 13. Ford CN. Evaluation and management of laryngopharyngeal reflux. JAMA. 2005; 294:1534e1540. 14. Vaezi MF, Hicks DM, Abelson TI, Richter JE. Laryngeal signs and symptoms and gastroesophageal reflux disease (GERD): a crit- ical assessment of cause and effect association. Clin Gastro- enterol Hepatol. 2003; 1:333e344. 15. De Bortoli N, Nacci A, Savarino E, et al. How many cases of laryngopharyngeal reflux suspected by laryngoscopy is gastroesophageal reflux disease-related. World J Gastro- enterol. 2012; 18:4363e4370. 16. Nunes HS, Pinto JA, Zavanela AR, Cavallini AF, Freitas GS, Garcia FE. Comparison between the reflux finding score and the reflux symptom index in the practice of otorhinolaryn- gology. Int Arch Otorhinolaryngol. 2016; 20:218e221.17. Mattoo O, Muzaffar R, Mir A, Yousuf A, Charag AH, Ahmad R. Laryngopharyngeal Reflux: Prospective study analysing various non-surgical treatment modalities for LPR. Int J Phonosurg Laryngol.2012; 2(1):5-8.