Human lung cancer harbors spatially-organized stem-immunity hubs that associate with response to immunotherapy
Creators
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1.
Massachusetts General Hospital
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2.
Broad Institute
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3.
Harvard Medical School
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4.
Brigham and Women's Hospital
Description
Data associated with Chen, Nieman, Spurrell et al "Human lung cancer harbors spatially-organized stem-immunity hubs that associate with response to immunotherapy" Nature Immunology, 2024.
(1) Multiplex RNA scope. Processed cell-level data from 3 datasets, separated into manually selected "Stem Immunity" regions and "Tumor" regions, in separate files.
(2) GeoMx. Unprocessed GeoMex data, with standard fields provided by Nanostring software.
(3) MERFISH. Transcript-level information, including CellPose and Baysor segmentation.
(4) Co-registered multispectral RNA and protein images. Processed cell-level data from 46 patients. Patient-level meta data information is available in supplementary table 1, tab B_Patient_Metadata. Fluorophore channel information is Figure 1a.
Files
tx_merfish_Pt73.csv
Files
(13.9 GB)
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