An Observational Study of Magnesium Sulphate Added as an Adjuvant to Intrathecal Levo-Bupivacaine Heavy in Patients with Mild Pregnancy Induced Hypertension Undergoing Caesarean Section
Authors/Creators
- 1. Junior Resident, Department of Anesthesiology, Gandhi Medical College, Bhopal, Madhya Pradesh, India
- 2. Associate Professor (Designated Professor), Department of Anesthesiology, Gandhi Medical College, Bhopal, Madhya Pradesh, India
- 3. Assistant Professor, Department of Anesthesiology, Gandhi Medical College, Bhopal, Madhya Pradesh, India
- 4. Professor and HOD, Department of Anesthesiology, Gandhi Medical College, Bhopal, Madhya Pradesh, India
Description
Background: Adequate analgesia following caesarean section decreases morbidity, improves early ambulation, patient outcome and facilitates care of the newborn baby. Intrathecal Magnesium sulphate, an NMDA antagonist has been shown to prolong analgesia without significant side effects in healthy parturients. Aims and Objectives: To study the effect of adding intrathecal Magnesium sulphate to 0.5% Levo-Bupuvacaine (heavy) in patients with mild pregnancy induced hypertension where blood pressure increases( i.e >140/90mmHg) after 20 weeks of gestation in women with previously normal blood pressure undergoing caesarean section. Materials and Methods: After obtaining consent, 60 patients of ASA I & II between the age group of 21 -35 years undergoing elective and semi-emergency caesarean section under spinal anaesthesia are randomly divided into two groups. Group C: Control group, N=30 patients 0.5% 2cc (10mg) Levobupivacaine heavy. Group M: Magnesium sulphate group, N=30 patients 0.5% 2cc (10mg) Levo-Bupivacaine heavy +0.1cc 50% (50mg) magnesium sulphate. Onset, duration and recovery of sensory and motor block, duration of spinal anesthesia and post-operative analgesia were recorded. Results: The addition of intrathecal magnesium sulfate prolonged the duration of spinal anesthesia by 42 minutes compared to the control group. Postoperative analgesic consumption over 24 hours was significantly lower in the magnesium group. Motor recovery time was prolonged in the magnesium group, but no significant hemodynamic effects were observed. Conclusion: Intrathecal magnesium sulfate as an adjuvant to spinal anesthesia in cesarean section for PIH patients prolongs spinal anesthesia duration and reduces postoperative analgesic consumption. While motor recovery time was prolonged, no significant hemodynamic effects were noted, indicating its safety and efficacy as an adjunct in obstetric anesthesia.
Abstract (English)
Background: Adequate analgesia following caesarean section decreases morbidity, improves early ambulation, patient outcome and facilitates care of the newborn baby. Intrathecal Magnesium sulphate, an NMDA antagonist has been shown to prolong analgesia without significant side effects in healthy parturients. Aims and Objectives: To study the effect of adding intrathecal Magnesium sulphate to 0.5% Levo-Bupuvacaine (heavy) in patients with mild pregnancy induced hypertension where blood pressure increases( i.e >140/90mmHg) after 20 weeks of gestation in women with previously normal blood pressure undergoing caesarean section. Materials and Methods: After obtaining consent, 60 patients of ASA I & II between the age group of 21 -35 years undergoing elective and semi-emergency caesarean section under spinal anaesthesia are randomly divided into two groups. Group C: Control group, N=30 patients 0.5% 2cc (10mg) Levobupivacaine heavy. Group M: Magnesium sulphate group, N=30 patients 0.5% 2cc (10mg) Levo-Bupivacaine heavy +0.1cc 50% (50mg) magnesium sulphate. Onset, duration and recovery of sensory and motor block, duration of spinal anesthesia and post-operative analgesia were recorded. Results: The addition of intrathecal magnesium sulfate prolonged the duration of spinal anesthesia by 42 minutes compared to the control group. Postoperative analgesic consumption over 24 hours was significantly lower in the magnesium group. Motor recovery time was prolonged in the magnesium group, but no significant hemodynamic effects were observed. Conclusion: Intrathecal magnesium sulfate as an adjuvant to spinal anesthesia in cesarean section for PIH patients prolongs spinal anesthesia duration and reduces postoperative analgesic consumption. While motor recovery time was prolonged, no significant hemodynamic effects were noted, indicating its safety and efficacy as an adjunct in obstetric anesthesia.
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IJPCR,Vol16,Issue1,Article243.pdf
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Additional details
Dates
- Accepted
-
2023-12-18
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue1,Article243.pdf
- Development Status
- Active
References
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