The Impact of Inhalation Steroids on Chronic Laryngitis Patients with Voice Change: A Prospective Study
Authors/Creators
- 1. Senior Resident, Gandhi Medical College, Bhopal, Madhya Pradesh, India
- 2. Senior Resident, MGM Medical College, Indore, Madhya Pradesh
- 3. Post Graduate Resident, Gandhi Medical College, Bhopal, Madhya Pradesh, India
Description
Background: Chronic laryngitis, a condition characterized by persistent inflammation of the laryngeal mucosa, frequently presents with voice changes, significantly impacting patients’ quality of life. Aims and Objectives: To assess the efficacy of inhalation steroids in ameliorating voice outcomes and reducing laryngeal inflammation in individuals diagnosed with chronic laryngitis experiencing voice alterations. Materials and Methods: Seventy-five participants, aged between 18 and 65 years, were recruited based on clinical and laryngoscopic examination findings confirming chronic laryngitis at the Otolaryngology outpatient clinic at a tertiary center of Central India. Between December 2022 and June 2023, participants were randomly assigned to either Group A (Fluticasone propionate; 2 puffs twice a day + standard care) or Group B (standard care alone) through computer-generated randomization, with allocation concealment ensured by sealed envelopes. Outcome measures encompassed acoustic voice analysis (jitter, shimmer, noise-to-harmonics ratio), perceptual voice analysis (overall voice quality, pitch, loudness), and laryngeal inflammation scores assessed at baseline and post-treatment evaluations. Results: Both groups exhibited comparable baseline characteristics (age, gender, duration of symptoms). Acoustic Analysis: Group A showed significant improvement in jitter (p<0.001), shimmer (p=0.002), and noise-to-harmonics ratio (p=0.001) compared to Group B. Perceptual Analysis: Group A demonstrated significant improvement in overall voice quality, pitch, and loudness compared to Group B (all p<0.001). Laryngeal Inflammation: Group A exhibited a substantial reduction in laryngeal inflammation scores compared to Group B (p<0.001). Conclusion: Incorporating inhalation steroids, specifically Fluticasone propionate, into the comprehensive management of chronic laryngitis with voice change yielded promising results, offering a potential avenue for enhancing patient outcomes and improving overall quality of life.
Abstract (English)
Background: Chronic laryngitis, a condition characterized by persistent inflammation of the laryngeal mucosa, frequently presents with voice changes, significantly impacting patients’ quality of life. Aims and Objectives: To assess the efficacy of inhalation steroids in ameliorating voice outcomes and reducing laryngeal inflammation in individuals diagnosed with chronic laryngitis experiencing voice alterations. Materials and Methods: Seventy-five participants, aged between 18 and 65 years, were recruited based on clinical and laryngoscopic examination findings confirming chronic laryngitis at the Otolaryngology outpatient clinic at a tertiary center of Central India. Between December 2022 and June 2023, participants were randomly assigned to either Group A (Fluticasone propionate; 2 puffs twice a day + standard care) or Group B (standard care alone) through computer-generated randomization, with allocation concealment ensured by sealed envelopes. Outcome measures encompassed acoustic voice analysis (jitter, shimmer, noise-to-harmonics ratio), perceptual voice analysis (overall voice quality, pitch, loudness), and laryngeal inflammation scores assessed at baseline and post-treatment evaluations. Results: Both groups exhibited comparable baseline characteristics (age, gender, duration of symptoms). Acoustic Analysis: Group A showed significant improvement in jitter (p<0.001), shimmer (p=0.002), and noise-to-harmonics ratio (p=0.001) compared to Group B. Perceptual Analysis: Group A demonstrated significant improvement in overall voice quality, pitch, and loudness compared to Group B (all p<0.001). Laryngeal Inflammation: Group A exhibited a substantial reduction in laryngeal inflammation scores compared to Group B (p<0.001). Conclusion: Incorporating inhalation steroids, specifically Fluticasone propionate, into the comprehensive management of chronic laryngitis with voice change yielded promising results, offering a potential avenue for enhancing patient outcomes and improving overall quality of life.
Files
IJPCR,Vol16,Issue1,Article100.pdf
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Additional details
Dates
- Accepted
-
2024-01-13
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue1,Article100.pdf
- Development Status
- Active
References
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