MR Spectroscopy in Evaluation of Cerebral Tumors
Authors/Creators
- 1. Assistant Professor, Department of Radiology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, Telangana, India
- 2. Junior Resident, Department of Radiology, Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar, Telangana, India
Description
Background: Intra axial brain tumors are a significant health problem and present several limiting challenges. These lesions include primary neoplasm (high and low grade), secondary (metastatic)neoplasm, lymphoma, tumefactive demyelinating lesions, abscesses and encephalitis. We are witnessing a shift in imaging from merely providing anatomical information towards providing information about tumor physiology. Aim/Objectives: (1) To determine biochemical markers of intra axial brain tumors using MR. (2) To evaluate role of MR spectroscopy in diagnosing and grading of intra axial brain tumor with histopathological co-relation. (3) To evaluate role of MR spectroscopy in determining the infiltrative nature of the intra axial brain. Materials and Methods: The main source of data for the study: Patients from the Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar. All patients referred to the, Department of Radiodiagnosis with clinically suspected brain tumors in a period from July 2022 to June 2023 will be subjected for the study. Results: The tumors showed decreased NAAC and Cr contents and a high cho signal. The Lac-Lip signal was high in grade III astrocytomas, glioblastomas. Reports that Cho/Cr ratio and Cho/NAA ratio increases with glioma’s whereas NAA/Cr decreases were confirmed with histopathological correlation. 20% of the patients with intra axial brain tumor were between 31 to 40 years of age. 73.33% of the patients were having intra axial brain tumors in supratentorial location. In this study majority of the patients i.e., 43.33% had hypointense signal on T1. Conclusion: Accurate grading of gliomas on the basis of MRS alone may be difficult. Combining MRS with conventional and other advanced MR imaging techniques, grading becomes more precise.
Abstract (English)
Background: Intra axial brain tumors are a significant health problem and present several limiting challenges. These lesions include primary neoplasm (high and low grade), secondary (metastatic)neoplasm, lymphoma, tumefactive demyelinating lesions, abscesses and encephalitis. We are witnessing a shift in imaging from merely providing anatomical information towards providing information about tumor physiology. Aim/Objectives: (1) To determine biochemical markers of intra axial brain tumors using MR. (2) To evaluate role of MR spectroscopy in diagnosing and grading of intra axial brain tumor with histopathological co-relation. (3) To evaluate role of MR spectroscopy in determining the infiltrative nature of the intra axial brain. Materials and Methods: The main source of data for the study: Patients from the Chalmeda Anand Rao Institute of Medical Sciences, Karimnagar. All patients referred to the, Department of Radiodiagnosis with clinically suspected brain tumors in a period from July 2022 to June 2023 will be subjected for the study. Results: The tumors showed decreased NAAC and Cr contents and a high cho signal. The Lac-Lip signal was high in grade III astrocytomas, glioblastomas. Reports that Cho/Cr ratio and Cho/NAA ratio increases with glioma’s whereas NAA/Cr decreases were confirmed with histopathological correlation. 20% of the patients with intra axial brain tumor were between 31 to 40 years of age. 73.33% of the patients were having intra axial brain tumors in supratentorial location. In this study majority of the patients i.e., 43.33% had hypointense signal on T1. Conclusion: Accurate grading of gliomas on the basis of MRS alone may be difficult. Combining MRS with conventional and other advanced MR imaging techniques, grading becomes more precise.
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Additional details
Dates
- Accepted
-
2023-07-25
Software
References
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