Role of Biochemical Markers in Acute Pancreatitis
Authors/Creators
- 1. AssistantProfessor, Department of Biochemistry, Kurnool Medical College, Kurnool
- 2. Associate Professor, Department of Biochemistry, Kurnool Medical College, Kurnool
- 3. Professor and H.O.D Department of Biochemistry, Kurnool Medical College, Kurnool
Description
Introduction: Acute Pancreatitis is a condition that is characterized by an acute inflammation of the pancreas. Patients who are experiencing significant acute upper abdominal pain should be suspected of having acute pancreatitis; nevertheless, in order to establish the diagnosis, it requires either biochemical or radiologic evidence. Aims and Objectives: The purpose of this study is to determine the role of biochemical marker in predicting acute pancreatitis. Methods: This is a Retrospective study conducted in Department of Biochemistry ,Government General Hospital, Kurnool from April 2023 to December 2023 .Data collected from the Medical records were age, Sex, Levels of Serum amylase and Lipase amylase lipase ratio. Results: Among the Total 90 patients males constituted 73.3% (n=66) and Females 26.7 % (n=24). The mean age and SD of the patients in this study group was 38.5±2.2.5years Mean and SD of Amylase, Lipase and Amylase Lipase Ratio was 870.3±754.23, 235.8±124.5 and 3.87±2.45. The sensitivity and specificity of amylase and Lipase at 3 fold above Normal limit were 83.33% and specificity 84.88 %. Positive predictive value 85.23% and Negative Predictive value 82.95%. Accuracy 84.09%. Conclusion: In patients with abdominal pain consistent with Acute Pancreatitis, the ACG practice guidelines consider lipase and/or amylase increase greater than 3 times ULN as diagnostic. Lipase is slightly more Acute Pancreatitis -specific than amylase. It rises earlier and stays higher than serum amylase in AP patients. Serum lipase outpaced serum amylase in diagnostic accuracy.
Abstract (English)
Introduction: Acute Pancreatitis is a condition that is characterized by an acute inflammation of the pancreas. Patients who are experiencing significant acute upper abdominal pain should be suspected of having acute pancreatitis; nevertheless, in order to establish the diagnosis, it requires either biochemical or radiologic evidence. Aims and Objectives: The purpose of this study is to determine the role of biochemical marker in predicting acute pancreatitis. Methods: This is a Retrospective study conducted in Department of Biochemistry ,Government General Hospital, Kurnool from April 2023 to December 2023 .Data collected from the Medical records were age, Sex, Levels of Serum amylase and Lipase amylase lipase ratio. Results: Among the Total 90 patients males constituted 73.3% (n=66) and Females 26.7 % (n=24). The mean age and SD of the patients in this study group was 38.5±2.2.5years Mean and SD of Amylase, Lipase and Amylase Lipase Ratio was 870.3±754.23, 235.8±124.5 and 3.87±2.45. The sensitivity and specificity of amylase and Lipase at 3 fold above Normal limit were 83.33% and specificity 84.88 %. Positive predictive value 85.23% and Negative Predictive value 82.95%. Accuracy 84.09%. Conclusion: In patients with abdominal pain consistent with Acute Pancreatitis, the ACG practice guidelines consider lipase and/or amylase increase greater than 3 times ULN as diagnostic. Lipase is slightly more Acute Pancreatitis -specific than amylase. It rises earlier and stays higher than serum amylase in AP patients. Serum lipase outpaced serum amylase in diagnostic accuracy.
Files
IJPCR,Vol16,Issue1,Article58.pdf
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Additional details
Dates
- Accepted
-
2023-12-26
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue1,Article58.pdf
- Development Status
- Active
References
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