Evaluation of Serum Gamma Glutamyl Transferase Levels in Pre Eclampsia Cases
Authors/Creators
- 1. Assistant Professor, Department of Biochemistry, Government Mohan Kumaramangalam Medical College, Steel Plant Road, Salem, Tamil Nadu, India
Description
Background: Preeclampsia is a Pregnancy Specific Syndrome characterised by Hypertension with BP 140/90 mm Hg or more, Proteinuria and edema contributing significantly to Maternal and Foetal Morbidity and Mortality. Endothelial cell dysfunction within the Uteroplacental circulation leads to systemic release of Gamma Glutamyl Transferase (GGT). Aim and Objectives: The main aim of this study is to compare the levels of Serum Gamma Glutamyl Transferase (GGT) levels in pre eclampsia patients and normal pregnancy patients and also to predict the severity of pre eclampsia with GGT. Materials and Method: This case control study was done from November 2017 to January 2018 at Mahatma Gandhi Memorial Government Hospital, Trichy, 30 pre eclampsia patients and 30 normal healthy normotensive pregnant women (controls) were enrolled in the study. All the cases were selected in the third trimester and belongs to the age group 19-35year. Cases with any medical history of hypertension, diabetes, renal disease, liver disease were excluded from the study. Controls were selected from the patients regularly attending the Antenatal clinic (ANC) and Preeclampsia cases were selected from the patients admitted in the ANC ward. The statistical analysis was performed using SPSS version 16. Results and Conclusion: The results were presented as a mean ± SD and p value of less than 0.001 is considered as significant. In our present study, the Serum GGT levels is found to be significantly increased in Pre- eclampsia Patients compared to Normal Pregnant Women with a p value ˂0.001. GGT is also useful in predicting the severity of pre eclampsia.
Abstract (English)
Background: Preeclampsia is a Pregnancy Specific Syndrome characterised by Hypertension with BP 140/90 mm Hg or more, Proteinuria and edema contributing significantly to Maternal and Foetal Morbidity and Mortality. Endothelial cell dysfunction within the Uteroplacental circulation leads to systemic release of Gamma Glutamyl Transferase (GGT). Aim and Objectives: The main aim of this study is to compare the levels of Serum Gamma Glutamyl Transferase (GGT) levels in pre eclampsia patients and normal pregnancy patients and also to predict the severity of pre eclampsia with GGT. Materials and Method: This case control study was done from November 2017 to January 2018 at Mahatma Gandhi Memorial Government Hospital, Trichy, 30 pre eclampsia patients and 30 normal healthy normotensive pregnant women (controls) were enrolled in the study. All the cases were selected in the third trimester and belongs to the age group 19-35year. Cases with any medical history of hypertension, diabetes, renal disease, liver disease were excluded from the study. Controls were selected from the patients regularly attending the Antenatal clinic (ANC) and Preeclampsia cases were selected from the patients admitted in the ANC ward. The statistical analysis was performed using SPSS version 16. Results and Conclusion: The results were presented as a mean ± SD and p value of less than 0.001 is considered as significant. In our present study, the Serum GGT levels is found to be significantly increased in Pre- eclampsia Patients compared to Normal Pregnant Women with a p value ˂0.001. GGT is also useful in predicting the severity of pre eclampsia.
Files
IJPCR,Vol16,Issue2,Article228.pdf
Files
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Additional details
Dates
- Accepted
-
2024-01-26
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue2,Article228.pdf
- Development Status
- Active
References
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