Assessment of Cardiovascular Autonomic Function in Individuals with Rheumatoid Arthritis
Authors/Creators
- 1. Tutor, Department of Physiology, Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar
- 2. JR-3, Department of Physiology, Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar
- 3. Professor and Head of Department, Department of Physiology, Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar
Description
Background: People all over the world suffer from inflammatory arthritis, such as rheumatoid arthritis (RA). Systemic inflammatory arthritis (RA) is a long-term autoimmune illness. It mostly affects the joints and is often associated with extra-articular symptoms such normochromic normocytic anemia, neuropathy, and rheumatoid nodules. This study aimed to assess cardiac autonomic function in rheumatoid arthritis patients and compare it to that of healthy individuals. Methods: From January to June of 2023, a cross-sectional study was conducted at the ANMMC, Gaya, Bihar, at the Department of Physiology. The investigation of autonomic functioning in RA was conducted on a group of 45±10-year-old males and females. There were fifty people in all; twenty-five were controls—healthy people not taking medication—and twenty-five had been diagnosed with RA using standards set by the American College of Rheumatology, along with matched pairs of controls based on sex. The history and examination details were entered into Performa. Patients were assessed for indications of potential dysfunctions of the autonomic nervous system (ANS). Result: This study involved 50 participants, divided into two groups: the Study group (Group – A) and the Control group (Group – B). Group A comprised twenty-five patients who received a rheumatoid arthritis diagnosis based on standards established by the American College of Rheumatology. Twenty-five healthy people made up Group B, who were not taking any medication to account for typical fluctuations. The valsalva maneuver and 30:15 ratio showed a lesser decline in the RA patients as compared to the control group, although the difference was not statistically significant (p>0.05). When comparing groups A to control, there was a substantial (P<0.01) decrease in the diastolic blood pressure change upon standing the blood pressure response. Conclusion: Cardiovascular autonomic function tests are useful in the early identification of autonomic dysfunction in this disease during normal clinical examinations. The overall assessment of all the tests conducted may yield more thorough information on autonomic function. In order to lower the cardiovascular autonomic morbidity in RA, evaluating autonomic function may be a routine clinical evaluation component.
Abstract (English)
Background: People all over the world suffer from inflammatory arthritis, such as rheumatoid arthritis (RA). Systemic inflammatory arthritis (RA) is a long-term autoimmune illness. It mostly affects the joints and is often associated with extra-articular symptoms such normochromic normocytic anemia, neuropathy, and rheumatoid nodules. This study aimed to assess cardiac autonomic function in rheumatoid arthritis patients and compare it to that of healthy individuals. Methods: From January to June of 2023, a cross-sectional study was conducted at the ANMMC, Gaya, Bihar, at the Department of Physiology. The investigation of autonomic functioning in RA was conducted on a group of 45±10-year-old males and females. There were fifty people in all; twenty-five were controls—healthy people not taking medication—and twenty-five had been diagnosed with RA using standards set by the American College of Rheumatology, along with matched pairs of controls based on sex. The history and examination details were entered into Performa. Patients were assessed for indications of potential dysfunctions of the autonomic nervous system (ANS). Result: This study involved 50 participants, divided into two groups: the Study group (Group – A) and the Control group (Group – B). Group A comprised twenty-five patients who received a rheumatoid arthritis diagnosis based on standards established by the American College of Rheumatology. Twenty-five healthy people made up Group B, who were not taking any medication to account for typical fluctuations. The valsalva maneuver and 30:15 ratio showed a lesser decline in the RA patients as compared to the control group, although the difference was not statistically significant (p>0.05). When comparing groups A to control, there was a substantial (P<0.01) decrease in the diastolic blood pressure change upon standing the blood pressure response. Conclusion: Cardiovascular autonomic function tests are useful in the early identification of autonomic dysfunction in this disease during normal clinical examinations. The overall assessment of all the tests conducted may yield more thorough information on autonomic function. In order to lower the cardiovascular autonomic morbidity in RA, evaluating autonomic function may be a routine clinical evaluation component.
Files
IJPCR,Vol16,Issue2,Article170.pdf
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Additional details
Dates
- Accepted
-
2024-01-26
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue2,Article170.pdf
- Development Status
- Active
References
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