Genome-wide association summary statistics for trail making phenotypes from UK Bioabnk, and Genes & Cognition study

This repository contains genome-wide association study (GWAS) summary statistics for the following executive function traits:

• Trail Making Numeric (TMN)
• Trail Making Alpha Numeric (TMA)
• Mental Plasticity (TMD = TMA − TMN)

These data are derived from the study:
“Genetic landscape of adult executive function reveals a cell-type specific developmental origin.”

For full methodological details, please refer to the original publication at:

Summary statistics are provided for:

1. Genes and Cognition (G&C)
2. UK Biobank (UKB)
3. Meta-analysis (G&C + UKB)

1. Genes and Cognition (G&C)

TMN: tmn_gwas_gc.txt

TMA: tma_gwas_gc.txt

TMD: tmd_gwas_gc.txt

2. UK Biobank (UKB)

TMN: tmn_gwas_ukb.txt

TMA: tma_gwas_ukb.txt

TMD: tmd_gwas_ukb.txt

3. Meta-analysis

TMN: tmn_meta.txt

TMA: tma_meta.txt

TMD: tmd_meta.txt

Column Descriptions: UKB and G&C Summary Statistics

SNP: rs identifier for the SNP

CHR: chromosome (GRCh37 build) 

BP: base pair (GRCh37 build) 

A1: effect allele 

A2: reference allele 

A1FREQ: effect allele frequency 

INFO: imputation information

CHISQ: Chi-square statistics

P: p-value 

BETA: effect size of effect allele

SE: standard error 

N: sample size

Column Descriptions: Meta-analysis Summary Statistics

A1: effect allele 

A2: reference allele 

A1FREQ: estimated frequency of the effect allele

FreqSE: standard error of the estimated effect allele frequency

MinFreq: minimum observed allele frequencies

MaxFreq: maximum observed allele frequencies

BETA: meta-analysed effect size

SE: standard error of the meta-analysed effect size

P: p-value

Direction: effect direction across studies (+ / − / ?)

HetISq: I² statistic (heterogeneity measure)

HetChiSq: Cochran’s Q statistic

HetDf: degrees of freedom for the heterogeneity test

HetPVal: p-value for heterogeneity

N: sample size contributing to the meta-analysis.

SNP: rs identifier for the SNP

CHR: chromosome (GRCh37 build) 

BP: base pair (GRCh37 build)