Prevalence, Clinical Presentation and Underlying Etiology of Bacterial Vaginosis: A Hospital-Based Cross-Sectional Study
Authors/Creators
- 1. Assistant Professor, Microbiology, A.H. Post-Graduate Institute of Cancer, Cuttack
- 2. Assistant Professor, Biochemistry, A.H. Post-Graduate Institute of Cancer, Cuttack
- 3. Assistant Professor, Microbiology, F.M. Medical College and Hospital, Balesore
- 4. Professor & H.O.D. Department of Microbiology, S.C.B. Medical College & Hospital, Cuttack
- 5. Ex Senior Research Fellow, A.H. Post-Graduate Institute of Cancer, Cuttack.
Description
Background: Bacterial vaginosis (BV) is the most common vaginal disorder, affecting a significant proportion of women. It’s wide spread prevalence and severe health implications make It a critical public health issue. Aim and Objectives: This study was done to identify the prevalence, microbiological characteristics, and underlying causes of BV. Materials and methods: This hospital-based case-control study was conducted on patients presenting with abnormal vaginal discharge, pregnant women, women experiencing preterm labor, women with a history of hysterectomy or medical termination of pregnancy (MTP), and women using intra uterine contraceptive devices (IUCDs). Results: Nearly half (48%) of bacterial vaginosis (BV) cases identified using the Nugent scoring system were found to harbor Gardnerella vaginalis (G.vaginalis) bacteria. A higher prevalence of G.vaginalis isolation was linked to an elevated vaginal pH, exceeding 4.5. Clue cell detection demonstrated a sensitivity of 69.23% and a specificity of 86.95%, while the amine test displayed a sensitivity of 73.07% and a specificity of 66.30%. Metronidazole, ampicillin, and chloramphenicol are effective antimicrobials against G.vaginalis infections. Conclusion: Bacterial vaginosis is a common health problem in women of reproductive age. Given the prevalence and adverse consequences of BV, implementing routine screening and effective management strategies is crucial to prevent future complications.
Abstract (English)
Background: Bacterial vaginosis (BV) is the most common vaginal disorder, affecting a significant proportion of women. It’s wide spread prevalence and severe health implications make It a critical public health issue. Aim and Objectives: This study was done to identify the prevalence, microbiological characteristics, and underlying causes of BV. Materials and methods: This hospital-based case-control study was conducted on patients presenting with abnormal vaginal discharge, pregnant women, women experiencing preterm labor, women with a history of hysterectomy or medical termination of pregnancy (MTP), and women using intra uterine contraceptive devices (IUCDs). Results: Nearly half (48%) of bacterial vaginosis (BV) cases identified using the Nugent scoring system were found to harbor Gardnerella vaginalis (G.vaginalis) bacteria. A higher prevalence of G.vaginalis isolation was linked to an elevated vaginal pH, exceeding 4.5. Clue cell detection demonstrated a sensitivity of 69.23% and a specificity of 86.95%, while the amine test displayed a sensitivity of 73.07% and a specificity of 66.30%. Metronidazole, ampicillin, and chloramphenicol are effective antimicrobials against G.vaginalis infections. Conclusion: Bacterial vaginosis is a common health problem in women of reproductive age. Given the prevalence and adverse consequences of BV, implementing routine screening and effective management strategies is crucial to prevent future complications.
Files
IJPCR,Vol16,Issue2,Article34.pdf
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Additional details
Dates
- Accepted
-
2023-12-18
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue2,Article34.pdf
- Development Status
- Active
References
- 1. Abbe C, Mitchell CM. Bacterial vaginosis: a review of approaches to treatment and prevention. Front Reprod Health. 2023; 5:1100029. 2. Koumans EH, Sternberg M, Bruce C, McQuillan G, Kendrick J, Sutton M, et al. The prevalence of bacterial vaginosis in the United States, 2001-2004; associations with symptoms, sexual behaviors, and reproductive health. Sex Transm Dis. 2007; 34:864-9. 3. Greenbaum S, Greenbaum G, Moran-Gilad J, Weintraub AY. Ecological dynamics of the vaginal microbiome in relation to health and disease. Am J Obstet Gynecol. 2019; 220:324- 335. 4. Verstraelen H, Swidsinski A. The biofilm in bacterial vaginosis: implications for epidemiology, diagnosis and treatment: 2018 update. Curr Opin Infect Dis. 2019; 32:38-42. 5. Turovskiy Y, Sutyak Noll K, Chikindas ML. The aetiology of bacterial vaginosis. Journal of applied microbiology. 2011; 110:1105-28. 6. Vodstrcil LA, Muzny CA, Plummer EL, Sobel JD, Bradshaw CS. Bacterial vaginosis: drivers of recurrence and challenges and opportunities in partner treatment. BMC Med. 2021; 19:194. 7. Kenyon C, Colebunders R, Crucitti T. The global epidemiology of bacterial vaginosis: A systematic review. Am J Obstet Gynecol 2013; 209: 505–23 8. Eade CR, Diaz C, Wood MP, et al. Identification and characterization of bacterial vaginosis-associated pathogens using a comprehensive cervical-vaginal epithelial coculture assay. PLoS One. 2012;7:e50106. 9. Reiter S, Kellogg Spadt S. Bacterial vaginosis: a primer for clinicians. Postgraduate medicine. 2019 Jan 2; 131:8-18. 10. Atashili J, Poole C, Ndumbe PM, Adimora AA, Smith JS. Bacterial vaginosis and HIV acquisition: a meta-analysis of published studies. AIDS (London, England). 2008; 22:1493. 11. Amsel R, Totten Pa, Spiegel Ca, Cken Kcs, Esckenback Da; 1983. Non specific vaginitis: Diagnostic criteria and microbial -and epidemiologic associations. Am J Med; 74 : 14- 21. 12. Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol. 1991; 29:297- 301. 13. Ranjit E, Raghubanshi BR, Maskey S, Parajuli P. Prevalence of Bacterial Vaginosis and Its Association with Risk Factors among Nonpregnant Women: A Hospital Based Study. Int J Microbiol. 2018; 2018:8349601. 14. Modak T, Arora P, Agnes C, Ray R, Goswami S, Ghosh P, et al. Diagnosis of bacterial vaginosis in cases of abnormal vaginal discharge: comparison of clinical and microbiological criteria. J Infect Dev Ctries. 2011; 5:353-60. 15. Vodstrcil LA, Muzny CA, Plummer EL, Sobel JD, Bradshaw CS. Bacterial vaginosis: drivers of recurrence and challenges and opportunities in partner treatment. BMC Med. 2021; 19:194. 16. Lata I, Pradeep Y, Sujata, Jain A. Estimation of the Incidence of Bacterial Vaginosis and other Vaginal Infections and its Consequences on Maternal/Fetal Outcome in Pregnant Women Attending an Antenatal Clinic in a Tertiary Care Hospital in North India. Indian J Community Med. 2010; 35:285-28917. Janulaitiene M, Paliulyte V, Grinceviciene S, Zakareviciene J, Vladisauskiene A, Marcinkute A, et al. Prevalence and distribution of Gardnerella vaginalis subgroups in women with and without bacterial vaginosis. BMC Infect Dis. 2017; 17:394 18. Tokyol C, Aktepe OC, Cevrioğlu AS, Altindiş M, Dilek FH. Bacterial vaginosis: comparison of Pap smear and microbiological test results. Mod Pathol. 2004; 17:857-860