RARE PRESENTATION OF SIGNET CELL ADENOCARCINOMA IN VICENARIAN: A CASE REPORT & LITERATURE REVIEW

Colorectal cancer (CRC) remains a significant contributor to cancer-related mortality, posing diagnostic and management challenges. Despite an overall decrease in CRC incidence, there has been an alarming rise in cases among young adults and adults. CRC, among various histopathological subtypes, signet ring cell carcinoma (SRCC) is comparatively infrequent but shows a higher prevalence in adults compared to older individuals. This subtype displays distinctive histological features, unique clinical characteristics, and unfortunately, a grim prognosis. Here, we present a primary case of signet ring cell adenocarcinoma located in the rectum, affecting a male of 29-year-old. The rare presentation and tumor's location in these cases underscore the need for further investigation and research. We have also conduct a comprehensive literature review pertaining to metastatic SRCC, shedding light on significant findings in this area. This underscores the critical role of collaboration between clinicians and pathologists, emphasizing the importance of thorough histopathological, immunohistochemical, and molecular analyses. Such analyses serve as valuable tools for guiding investigations and facilitating informed management decisions.

Keywords: Signet ring cell carcinoma, colorectal cancer, grim prognosis, rectum