FORMULATION AND EVALUATION OF PERINDOPRIL ORAL DISINTEGRATING TABLETS

Abstract:

Difficulty in swallowing is common among all age groups especially elderly and pediatrics. Oral disintegrating tablets may constitute and innovative dosage form that overcome the problem of swallowing and provide a quick onset of action. This study was aimed to formulate and evaluate an orally disintegrate tablet (ODT) containing Perindopril while using Superdisintegrants. Oral disintegrate tablets were prepared by direct compression by using Superdisintegrants Croscarmellose Sodium, Crospovidone and Sodium starch glycolate. The prepared tablets were evaluated for hardness, friability, thickness, drug content uniformity. According to the results of optimized batches the concentration of superdisintegrant were given rapid disintegration in 24 seconds which showed 99.78 % drug release within 45 minutes. Crospovidone superdisintegrant, gives a rapid disintegration and when used in formulation of ODT.

Key Words: Perindopril, Croscarmellose Sodium, Crospovidone, Sodium starch glycolate and Oral Disintegrating Tablets.