Periodontitis and Alzheimer's Disease: A Possible Comorbidity between Oral Chronic Inflammatory Condition and Neuroinflammation
Authors/Creators
- 1. Institute of Biological Science, Federal University of Pará, Belém, Brazil
- 2. College of Medicine, Federal University of Pará, Altamira, Brazil
- 3. Dental School, Brazil-Amazon Integrated Faculty, Belém, Brazil
- 4. Department of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, Brazil
- 5. Institute of Health Science, Federal University of Pará, Belém, Brazil
Description
Periodontitis is an oral chronic infection/inflammatory condition, identified as a source of mediators of inflammation into the blood circulation, which may contribute to exacerbate several diseases. There is increasing evidence that inflammation plays a key role in
the pathophysiology of Alzheimer’s disease (AD). Although inflammation is present in both diseases, the exact mechanisms and crosslinks between periodontitis and AD are poorly understood. Therefore, this article aims to review possible comorbidity
between periodontitis and AD. Here, the authors discuss the inflammatory aspects of periodontitis, how this oral condition produces a systemic inflammation and, finally, the contribution of this systemic inflammation for worsening neuroinflammation in the progression of AD.
Files
fnagi-09-00327.pdf
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Additional details
Identifiers
Dates
- Other
-
2017-09-19Received
- Accepted
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2017-09-21
References
- TEIXEIRA, FRANCISCO B. ; SAITO, MIKI T. ; Matheus, Filipe C. ; PREDIGER, RUI D. ; YAMADA, ELIZABETH S. ; MAIA, CRISTIANE S. F. ; LIMA, RAFAEL R. . Periodontitis and Alzheimer?s Disease: A Possible Comorbidity between Oral Chronic Inflammatory Condition and Neuroinflammation. Frontiers in Aging Neuroscience, v. 9, p. 1-9, 2017.