A Review On 1,2,4-Triazoles

ABSTRACT

Triazole is a five membered heterocyclic system consisting of two carbon atoms and three nitrogen atoms shows wide range of biological activities. Triazoles can be synthesized using Einhorn-Brunner reaction or the Pellizzari reaction from acyl hydrazides and various different method. Triazole derivatives are showing very promising and excellent therapeutic effectiveness. The major activities exhibited by these derivatives include insecticial, antifungal, antiviral, antibacterial, sedative,hypnotic, anticonvulsant and anti-inflammatory action. In recent year heterocyclic compounds analogues and derivatives have attracted strong interest due to their useful biological and pharmacological properties. The small and simple triazole nucleus is present in compounds involved in research aimed at evaluating new products that possess biological activities, such as,anti-microbial, anti-tumor, anthelmintic, anti-leishmanial, anti-convulsant and anti-inflammatory.

Key words: Triazole, 1H-1, 2,4-Triazole, Heterocycle, Total synthesis, Biological activities.