PROGNOSTIC SIGNIFICANCE OF SOCS IN REGULATING CANCER PROGRESSION
Authors/Creators
- 1. Department of Biomedical Engineering, University of North Texas, 3940 N Elm Street, Denton, TX, USA.
- 2. Department of Rehabilitation and Health Services, University of North Texas, 3940 N Elm Street, Denton, TX, USA.
- 3. Department of Biotechnology, KL University, Vaddeswaram, Guntur, Andhra Pradesh, India.
- 4. Department of Biotechnology, Anwarul Uloom College, Osmania University, Hyderabad, Telangana, India.
- 5. Department of Molecular Biology, Cresent Biosciences, ICRAB Campus, Kanpur, Uttar Pradesh, India.
Description
Suppressor of cytokine signalling (SOCS) proteins have emerged as crucial regulators in cancer progression, exhibiting significant prognostic implications. This review explores the prognostic significance of SOCS in various cancer types and their role in modulating key signalling pathways involved in tumour growth, metastasis, and immune evasion. Understanding the intricate interplay between SOCS proteins and cancer progression provides valuable insights into developing targeted therapies and prognostic markers for improved patient management and outcomes. SOCS proteins are pivotal regulators of immune responses and inflammation, but their dysregulation has been implicated in cancer development and progression. We explore the mechanisms by which SOCS proteins exert their effects on oncogenic signalling pathways, such as JAK/STAT, PI3K/AKT, and MAPK pathways, highlighting their potential as therapeutic targets. Furthermore, understanding the complex interplay between SOCS proteins and cancer holds promise for the development of novel therapeutic strategies and precision medicine approaches tailored to individual patients.
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