SYNTHESIS AND BIOLOGICAL ACTIVITIES OF QUINOLINES

Quinoline, a N-based aromatic compound has numerous applications in various industries, including pharmaceuticals, agrochemicals, dyestuffs, and materials. It has antiprotozoal, antitubercular, anticancer, antipsychotics, anti-inflammatory, antioxidant, anti-HIV, antifungal, efflux pump inhibitors, neurodegenerative diseases and lupus treatment. Quinine and quinidine alkaloids from Cinchona bark contain quinoline scaffolds, making it a key component in clinically used drugs. Various methods have been developed to synthesize quinoline derivatives, including the Gould-Jacob quinoline synthesis, Friedlander quinoline synthesis, Pfitzinger quinoline synthesis, Skraup/Doebner-von Miller quinoline synthesis, and Combes/Conrad-Limpach synthesis.

Keywords; Agrochemicals, Cinchona, cyclodehydration, hypotensive effects,  rheumatoid arthiritis