Assessment of Glycation Gap in Diabetes Mellitus Patients
Authors/Creators
- 1. MSc, Ph.D., Assistant Professor of Biochemistry, Shri Sathya Sai Medical College and Research institute, Sri Balaji Vidyapeeth Deemed to be University, Guduvancherry-Thiruporur Main Road, Ammapettai, Chengalpet district: 603108
- 2. M.D, Professor of Biochemistry, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth Deemed to be University
- 3. M.D, Professor & HOD of Biochemistry, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth Deemed to be University
Description
Glycated hemoglobin (HbA1c) is a most preferred test for monitoring of diabetes mellitus patients but it is altered under certain conditions so fructosamine is used as an alternative for short term monitoring of blood glucose levels. HbA1c can be calculated from serum fructosamine. The difference between measured and calculated HbA1c is called glycation gap. This gap is altered under different glycation conditions which may serve as a simple tool to monitor the glycation levels. The aim of the present research study is to compare the serum fructosamine and HbA1c and then to calculate and assess the glycation gap in diabetic patients without complications. In our study, 72 diabetic patients without complications were included and based on serum fructosamine values they are divided into three groups. Serum fructosamine, HbA1c and Hemoglobin were measured. Calculated HbA1c values are obtained using calculated HbA1c-fructosamine regression equation. The difference between measured and calculated HbA1c termed the glycation gap was calculated for all the cases. The relationship between these parameters was graphically analyzed. Mean and standard deviation was calculated for all the 3 groups and one way statistical analysis test was done. The glycation gap was found to be negative in all these cases and statistically significant between the three groups.
Abstract (English)
Glycated hemoglobin (HbA1c) is a most preferred test for monitoring of diabetes mellitus patients but it is altered under certain conditions so fructosamine is used as an alternative for short term monitoring of blood glucose levels. HbA1c can be calculated from serum fructosamine. The difference between measured and calculated HbA1c is called glycation gap. This gap is altered under different glycation conditions which may serve as a simple tool to monitor the glycation levels. The aim of the present research study is to compare the serum fructosamine and HbA1c and then to calculate and assess the glycation gap in diabetic patients without complications. In our study, 72 diabetic patients without complications were included and based on serum fructosamine values they are divided into three groups. Serum fructosamine, HbA1c and Hemoglobin were measured. Calculated HbA1c values are obtained using calculated HbA1c-fructosamine regression equation. The difference between measured and calculated HbA1c termed the glycation gap was calculated for all the cases. The relationship between these parameters was graphically analyzed. Mean and standard deviation was calculated for all the 3 groups and one way statistical analysis test was done. The glycation gap was found to be negative in all these cases and statistically significant between the three groups.
Files
IJPCR,Vol16,Issue3,Article192.pdf
Files
(515.4 kB)
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Additional details
Dates
- Accepted
-
2024-02-26
Software
- Repository URL
- https://impactfactor.org/PDF/IJPCR/16/IJPCR,Vol16,Issue3,Article192.pdf
- Development Status
- Active
References
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