A Hospital-Based Study Destemming the Clinical Implication of Serum Uric Acid, Serum Calcium, Serum Creatinine and Serum Electrolytes in Patients with Kidney Stone
Authors/Creators
- 1. Senior Resident, Department of Surgery, Government Medical College and Hospital, Bettiah, Bihar, India
- 2. Assistant Professor and HOD, Government Medical College and Hospital, Bettiah, Bihar, Indi
Description
Aim: The aim of the present study was to assess the clinical significance of serum uric acid, serum calcium, serum
creatinine and serum electrolytes in patients with kidney stone.
Methods: The present study was conducted in the Department of Surgery and 200 patients were included in the
study. The patients were divided into two groups according to serum UA levels: the UA-high group with
hyperuricemia (serum UA ≥ 7.0 mg/dL) or the UA-low group with normal UA levels (serum UA < 7.0 mg/dL)
groups.
Results: Patient background was significantly different between the UA stone patients and the patients with
Coax/CaP stones in age, sex, body mass index, HTN, DM, CVD, hemoglobin, serum Alb, serum UA,
hyperuricemia, triglyceride, and stage 3 CKD. The UA-low group comprised 50 control subjects and pair-matched
25 patients with UA stones. There were no statistically significant differences in background between UA stone
patients and control subjects. The UA-high group comprised 10 patients with UA stones and 20 pair-matched
control subjects. There were no statistically significant differences in background between UA stone patients and
control subjects. The UA-low group comprised pair-matched 20 patients with CaOx/CaP and 20 patients with UA
stones. There were no statistically significant differences in background between UA stone patients and CaOx/CaP
patients. The UA-high group comprised 10 patients with CaOx/CaP and pair-matched 10 patients with UA stones.
There were no statistically significant differences in background between UA stone patients and control subjects.
Conclusion: Patients with UA stones had significantly worse renal function than controls and CaOx/CaP patients
regardless of hyperuricemia. Urolithiasis (CaOx/CaP and UA stone) and hyperuricemia had an association with
impaired renal function. Our findings encourage clinicians to initiate intensive treatment and education approaches
in patients with urolithiasis and/or hyperuricemia in order to prevent the progression of renal impairment.
Abstract (English)
Aim: The aim of the present study was to assess the clinical significance of serum uric acid, serum calcium, serum
creatinine and serum electrolytes in patients with kidney stone.
Methods: The present study was conducted in the Department of Surgery and 200 patients were included in the
study. The patients were divided into two groups according to serum UA levels: the UA-high group with
hyperuricemia (serum UA ≥ 7.0 mg/dL) or the UA-low group with normal UA levels (serum UA < 7.0 mg/dL)
groups.
Results: Patient background was significantly different between the UA stone patients and the patients with
Coax/CaP stones in age, sex, body mass index, HTN, DM, CVD, hemoglobin, serum Alb, serum UA,
hyperuricemia, triglyceride, and stage 3 CKD. The UA-low group comprised 50 control subjects and pair-matched
25 patients with UA stones. There were no statistically significant differences in background between UA stone
patients and control subjects. The UA-high group comprised 10 patients with UA stones and 20 pair-matched
control subjects. There were no statistically significant differences in background between UA stone patients and
control subjects. The UA-low group comprised pair-matched 20 patients with CaOx/CaP and 20 patients with UA
stones. There were no statistically significant differences in background between UA stone patients and CaOx/CaP
patients. The UA-high group comprised 10 patients with CaOx/CaP and pair-matched 10 patients with UA stones.
There were no statistically significant differences in background between UA stone patients and control subjects.
Conclusion: Patients with UA stones had significantly worse renal function than controls and CaOx/CaP patients
regardless of hyperuricemia. Urolithiasis (CaOx/CaP and UA stone) and hyperuricemia had an association with
impaired renal function. Our findings encourage clinicians to initiate intensive treatment and education approaches
in patients with urolithiasis and/or hyperuricemia in order to prevent the progression of renal impairment.
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Additional details
Dates
- Accepted
-
2024-03-17