Antimicrobial Activity Of Indole, Benzimidazole And Benzotriazole And Application In Drug Discovery: Review

Antibiotic resistance is often used to describe drug resistance, which occurs when bacteria, viruses, fungi, and parasites develop resistance to drugs intended to treat infections. Recent studies have confirmed that indole derivatives, heterocyclic benzimidazole derivatives and benzotriazole derivatives have antimicrobial activity against various microorganisms. Indole derivatives have attracted wide attention due to their diverse biological and clinical applications. Indole derivatives have antimicrobial activity against various microorganisms, including MRSA. Benzimidazole is a heterocyclic aromatic organic compound that has become an important pharmacophore and preferred structure in medicinal chemistry. Benzimidazole is a very effective compound in terms of antibacterial activity. Biochemical and pharmacological studies show that this molecule is active against several microbial species. Azoles, especially the benzotriazole ring, play an important role in heterocyclic chemistry and medicine. Benzotriazole derivatives are an important class of nitrogen-containing heterocycles believed to have a variety of pharmacological effects, including sedative, analgesic, antibacterial, and antifungal effects. In this review we discusses indoles, benzimidazoles and benzotriazoles for their antibacterial activity.