Data from: The neural basis of resting-state fMRI functional connectivity in fronto-limbic circuits revealed by chemogenetic manipulation

Included are raw neuroimaging and preprocessed neural recording data from "The neural basis of resting-state fMRI functional connectivity in fronto-limbic circuits revealed by chemogenetic manipulation" (see Related Works section; citation will be updated after publication). Please cite this paper if you use any of these data. Refer to the linked github repository for associated code.

Neuroimaging data is organized in BIDS format and saved as NIfTI files. We used MION (monocrystalline iron oxide nanoparticle) as a contrast agent. Functional resting state files can be found in the 'func' folder for each imaging session. The final six runs are resting state data (the first two/three are short EPI sequences used to test that MION is present in the brain; all resting state data used in our analyses consist of 300 volumes). The first three of these six runs consist of baseline data with no drug treatment. Four through six are resting state data recorded after I.M. injection of vehicle (2% DMSO in saline), dechloroclozapine (DCZ) or clozapine-N-oxide (CNO). 

Neural recording data is separated into LFP data, organized by folder, and putative single units, organized the 'Sorted neurons' folder. LFP data folders are named by subject's intial and date of recording. Single units are labeled according to this same system. All data are stored in .mat format and can be opened in MATLAB. KB2.mat files store timing information: the first event in the KBD2 file indicates the start of baseline, pre-injection data acquisition, and the second event indicates the start of post-injection treatment data. The KB3.mat files contains the timing information of the drug injection. As with the fMRI data, we treated animals with I.M. injection of vehicle, DCZ, or CNO. 

Treatment information for both modalities is as follows. Neuroimaging: 2020/03/16 Animal L DCZ 1; 2020/05/27 Animal H vehicle 1; 2020/06/01 Animal L vehicle 1; 2020/06/08 Animal H DCZ 1; 2020/06/22 Animal L DCZ 2; 2020/06/24 Animal H vehicle 2; 2020/07/06 Animal L vehicle 2; 2020/07/08 Animal H DCZ 2; 2021/10/25 Animal L CNO; 2022/01/13 Animal H CNO. Neural recordings: 2022/04/14 Animal H DCZ 1; 2022/04/21 Animal H vehicle 1; 2022/05/12 Animal H DCZ 2; 2022/05/24 Animal H vehicle 2; 2022/06/03 Animal H CNO; 2022/08/18 Animal L vehicle 1; 2022/08/25 Animal L DCZ 1; 2022/09/01 Animal L DCZ 2; 2022/09/08 Animal L vehicle 2; 2022/09/22 Animal L CNO.