ROLE OF VITAMIN C AND E AGAINST CADMIUM TOXICITY IN FEMALE WISTAR ALBINO RATS OVARIES, LIVER AND KIDNEY

Cadmium is a heavy metal present almost everywhere in the environment and it causes toxicity to different organs of body in female wistar albino rats. Cadmium exposure causes adverse effect to different target organs like kidney, liver and ovaries. The purpose of present study is to evaluate effect of vitamin C and E against cadmium toxicity in female wistar rats. Rats are divided in four groups and we provide different does of cadmium (3/5/7mg/lit) with vitamin C and vitamin E (100mg/kg b.w.). Vitamin C and E shows recovery effect against cadmium toxicity in different organs. The tissue and blood sample were taken from rats for histological analysis after 14 days. Hematological analysis, serum biochemical analysis histopathology of kidney, liver and ovarian tissue of different group of female treated with 3/5/7 mg/lit and (100 mg/kg) show recovery effect of ovary, liver and kidney. The result obtained from present study show protective effect against cadmium toxicity. Vitamin C and E has beneficial effect in the amelioration of cadmium toxicity in female wistar rats.

Keywords: Cadmium, vitamin C, Vitamin E, protective effect, wistar rats, ovary, liver, kidney, heavy metal.