SYNTHESIS AND CHARACTERIZATION OF ZINC OXIDE NANOPARTICLES LOADED WITH CARDIOSPERMUM HALICACABUM ALCOHOLIC EXTRACT.

In the present study, the use of natural herb i.e, Cardiospermum halicacabum has various medicinal applications including treatment of rheumatism, abdominal pain, dropsy, lumbago, skin diseases, cough, nervous disorders etc., Zinc oxide nanoparticles were loaded with Cardiospermum halicacabum aerial part extract and were synthesized successfully by the chemical reduction method. Nanotechnology deals with the processing of separation, consolidation, and deformation of materials by one atom or by one molecule. The foremost conditions for the synthesis of nanoparticles are the selection of green or environment-friendly solvent, a good reducing agent, and a harmless material for stabilization. Zinc oxide nanoparticles, loaded with Cardiospermum halicacabum aerial part extract. A detailed characterization of synthesized nanoparticles was carried out using different techniques such as UV visible spectroscopy, Fourier transforms infrared spectroscopy (FT- IR), X-Ray diffraction (XRD), Differential scanning calorimetry (DSC), Thermogravimetry analysis (TGA), Scanning electron microscopy(SEM). A Quantitative technique (UV-vis spectroscopy) is used to measure the absorption and transmission of synthesis nanoparticles as a function of wavelength. The XRD studies are used to analyze the structure and nature of the synthesized nanoparticles. Scanning electron microscopy (SEM) is used to analyze to obtain a high- resolution image of the size and morphological of synthesized nanoparticles. Thermal analytical techniques such as TGA &DSC are used for the determination of thermal properties at different conditions as mass, heat, temperature, and time.

Key Words: Nanoparticles, Drug delivery carrier, Cardiospermum halicacabum, Characterization.