Dataset: Fear learning induces synaptic potentiation between engram neurons in the rat lateral amygdala
Authors/Creators
-
1.
University Hospital of Lausanne
-
2.
University of Lausanne
-
3.
École Polytechnique Fédérale de Lausanne
- 4. The University of Tokyo Graduate School of Medicine
Description
The lateral amygdala (LA) encodes fear memories by potentiating sensory inputs associated with threats and, in the process, recruits 10-30% of its neurons per memory engram. However, how the network within the LA processes this information, and whether it also plays a role in storing it, is still largely unknown. Using ex vivo 12 patch clamp and in-vivo 32 electrode electrophysiological recordings, in combination with activity-dependent fluorescent and optogenetic tagging and recall, we identified between principal LA neurons in rats a sparsely connected network that is organized in clusters and in which connections between recruited neurons specifically potentiate after fear learning. Our findings of synaptic plasticity in an auto-associative excitatory network of the LA suggest a basic cortical principle through which a small number of pyramidal neurons could encode a large number of memories.
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Additional details
Related works
- Is published in
- Publication: 10.1038/s41593-024-01676-6 (DOI)
Funding
- Swiss National Science Foundation
- Synapsis Foundation
- Japan Society for the Promotion of Science