PRONIOSOMES OF NOVEL DRUG DELIVERY SYSTEM

The present article depicts an elaborative study of proniosomes as specialized drug delivery system. Proniosomes are dry formulation of water-soluble carrier particles that are coated with surfactant and can be measured out as needed and dehydrated to form niosomal dispersion immediately before use on  brief agitation in hot aqueous  media within  minutes. Provesicular  systems, such  as proniosomes  which  is one  of the  advancement  in nanotechnology  minimize  problems of vesicular systems such  as aggregation, fusion and  leakage of drug and  provide additional convenience in  transportation, distribution, storage and dosing. Conventional vesicular systems such as liposomes and niosomes are particulate in nature and face stability related difficulty.  The review article provides an insight about  these approaches  along  with  a novel vesicular approach known as proniosomes. This new emerging concept has demonstrated the potential in improving the oral bioavailability, targeting drugs to the specific site and also permeation of drugs across the stratum corneum. It prolongs the existence of  the drug in systemic circulation  and finally reduces the  toxicity. The goal of  this study is to  introduce and explore proniosomes as a carrier system for various pharmaceutical and cosmeceutical applications

Key words: Proliposomes , Cosmeceutical , Bioavailability ,Permeation , Conventional vescicular system , Nanotechnology.